Clinical Research Of Heat-Clearing And Dieresis-Promoting,Blood-Activating And Detoxification Granule’s Treatment For Gout Dampness-Heat Syndrome

Objectives Summarize the research team in recent years clinical experience treating gout, through comparative analysis before and after treatment of gout symptom score, pain relief time, laboratory tests, etc., evaluation clearing blood detoxification treatment of gout particles heat Accumulation permit clinical efficacy, with a view to clearing the hospital blood detoxification granules made preparations to facilitate further clinical application, patients were freed from the pain and economic burden.MethodsBased on randomly compared methods and in accordance with inclusion criteria, the study collected information from patients conceived of gout dampness-heat stagnation at Wangjing Hospital of China Academy of Chinese Medical Sciences during the period of February2012to January2014. The65patients were randomly divided into treatment group (33cases) and control group (32cases). The control group ueses diclofenac sodium sustained release tablets, twice daily, taking75mg every time; the treatment group pluses clearing heat and promoting diuresis and promoting blood circulation and detoxication On the basis of the control group, one dose daily in two times, once in the morning and once in the evening, about200ml warm water a blunt every time. Both groups take adjusting life style and controlling diet structure and sodium bicarbonate tablets, three times a day, each time taking0.5g in the morning, noon and night, as basic treatment, both groups take7days as an observation period. Evaluating the clinical effects by gout symptoms rating scale, treatment of gout symptom score, pain relief time, laboratory tests.Results1Comparison of the baseline of the two groupsThe patient’s age, sex, vital signs, course, past history and allergies, gout scale score in distribution between the two groups showed no significant difference in statistics(p>0.05), which indicates the two groups are comparable.2Comparison of the clinical efficacy of treatment in both groups Gout experimental group and the control group in each entry Scale score and score improvement after treatment group and between groups were highly statistically significant (compare scores between the two groups except p=0.006, more than both p<0.001); The onset time of pain between the two groups, the difference was statistically significant, indicating that the test group compared with the control group, pain relief more quickly; Experimental group, the total effective rate was93.94%in the control group, the total efficiency of78.13%, the difference was statistically significant (p=0.002). Description of symptoms after treatment have improved, while the experimental group than the control group to improve the symptoms of greater effectiveness.3Comparison of laboratory parameters after three treatment groupsErythrocyte sedimentation rate, C-reactive protein, serum uric acid index difference between the value of the group after treatment were highly statistically significant (except the control group p=0.002uric acid, the remainder are all p0.001), serum uric acid after treatment with there were statistically significant (p=0.006), explained after treatment laboratory indicators have decreased the difference between the baseline group, but the experimental group in terms of lowering blood uric acid effect is more prominent, still can not believe that between the two groups in improve erythrocyte sedimentation rate, C-reactive protein aspects vary.4Comparison of safety after four treatment groupsBlood, liver and kidney function after treatment were not unusual, the control group had two cases of gastrointestinal symptoms of nausea, the rank test p>0.05, still can not believe that there is significant difference between the two groups of adverse events. Judged medication may be associated with adverse events, are adverse reactions. Conclusions1.Joint clearing blood detoxification particles and simple use of sustained-release tablets of diclofenac sodium diclofenac sodium sustained release tablets in the treatment of gout heat Accumulation permits to improve joint pain, tenderness, swelling, limited mobility and laboratory parameters have a significant effect; But clearing and promoting blood circulation detoxification particle diclofenac sodium sustained release tablets to treat gout combined heat Accumulation permit the use of diclofenac sodium sustained release tablets than a simple treatment is effective, the total effective rate.2.Joint clearing blood detoxification particle diclofenac sodium sustained release tablets to treat gout heat Accumulation permit the use of diclofenac sodium delayed-release tablets than a simple treatment onset time soon.3.Joint clearing blood detoxification particle diclofenac sodium sustained release tablets to treat gout heat Accumulation card with good security.4.Clearing blood detoxification treatment of gout particles heat Accumulation permit safe, efficient and can be developed into a hospital preparations for its clinical application and promotion.