The Comparative Study Of Clinical Efficacy Of Alfuzosin And Tamsulosin For Ureteral Calculus

Objective:To compare the clinical efficacy of Tamsulosin and Alfuzosin for ureteralcalculus by prospective randomized controlled trials, thus providing the foundation for theclinical rational use of drug.Methods:304pations who had been diagnosed with ureteral calculus according to theclinical diagnosis, laboratory analsis, imaging tests in our urology outpatient clinicswere randomly divided into group A(Alfuzosin) and group B(Tamsulosin). All thepatients drank2000ml～3000ml water being evenly distributed within day and nightduring the therapy. Detailing record were kept about the site and size of stones of patients.And the record ended with removal of all clcui or changed with operation. Patients withrenal colic were evaluate by numerical pain rating scale(NRS), and methods of reviewingfacial expressions and inquiring subjective feeling were also used to evaluate the painsymptoms of patients.Results: In this study, the test group contained160patients,131male,29female, the agerange form21to61, the mean age was37.33±10.12. The control group contain160patients,120male,40female, the age range form19to60, the mean age was37.44±11.12. Both groups could promote expelling calculi, but the control group weresignificantly different (P﹤0.05) in the removal rate and time of calculi；the total curativeeffects of two groups were significantly different (P﹤0.05); There were no significantdifference (P﹥0.05) between the removal rate and time of middle and upper ureteralcalculi, but there were significant difference (P﹤0.05) between the removal rate and timeof lower ureteral calculi; two groups were not significantly different (P﹥0.05) for theremoval rate when calculi≤5mm, however with significant difference in removal time;two groups were significantly different (P﹤0.05) in the removal rate and time of calculiwhen the calculi≥5mm, and both were significantly different (P﹤0.05) for relievingrenal colic.There were no significant difference (P﹥0.05) in the adverse reaction betweentwo groups. And control group was superior to test group for cost-effect.Conclusion:1. Tamsulosin and alfuzosin can promote the excretion of ureteral stones, shorten time to stone expulsion.2. There were no significant difference in the removal rateof middle and upper ureteral calculi between Tamsulosin and Alfuzosin. Tamsulosin wassuperior to Alfuzosin. Comparing the overall effect of expelling stones of two drugs,Tamsulosin performed better.3.For ureteral calculi≤5mm, both drugs could promoteexpelling calculi, shortened the removing time with no significant difference; however, forureteral calculi≥5mm, Tamsulosin performed better.4.Tamsulosin was superior toAlfuzosin in relieving renal colic.5.Tamsulosin and alfuzosin therapy is safe and effectivefor ureteral calculi, nosignificant adverse reactions. Adverse reactions of the two drugswas no significant difference.6. Tamsulosin cost-effective than alfuzosin.