Association Of TCF7L2Polymorphisms With Polycystic Ovary Syndrome:a Meta-Analysis

Objective:To evaluate the association between TCF7L2rs7903146, rs290487polymorphisms and polycystic ovary syndrome.Methods:A systematically literature search was performed by using electronic databases including PubMed, EMbase,Cochrane Library, SinoMed, CNKI and WANFANG DATA. Through assessing the study quality heterogeneity, we can screen the literature that we need, and than extract the basic data.ORs and their95%CI were used to assess the strength of association between TCF7L2rs7903146, rs290487polymorphisms and polycystic ovary syndrome.Results:Five studies were selected for rs7903146polymorphism (1661cases and2866controls) and4studies (1544patients and1134controls) for rs290487polymorphism. Overall, pooled results showed that rs7903146polymorphism was not significant associated with PCOS risk(OR:0.98-1.10;95%CI:0.85-0.91to1.13-1.41). However, this meta-analysis revealed that the C allele in the rs7903146polymorphism was associated with a statistically significant increase in the risk of PCOS (OR:1.11-1.46;95%CI:0.94-1.14to1.31-1.89)Conclusion:In summary, a positive association correlation was observed between frequencies of the rs290487polymorphism and PCOS, but not such correlation was found with regard to the frequency of the rs7903146polymorphism.