The Study On The Synthesis Of Milnacipran

The research history, category, current research status and development trend of the antidepressants as well as the three classic routes for the synthesis of Milnacipran were introduced in this paper.As there were few reports about the synthesis programs of Milnacipran as an antidepressant drug, a new synthesis route was introduced in this paper. Mi-lnacipran was synthesized from phenylacetonitrile and2-chloro-methyloxirane i-n the presence of sodium tert-butoxide to give the efficient intermediate named1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one which underwent bromination, acylchlo-ridation, amidation and Derepine reaction with an overall yield of29%. In the process of experiment, the main factors on each reaction were exploredand and the reaction conditions were optimized.At the end, both the intermediates and target compound were characterized by1HNMR,13C NMR and IR.