Effect Of Serum Uric Acid Concentration On Short-term Outcome In Patients With Acute Stroke Treated With Thrombolysis

Objective:To investigate the impact of serum uric acid concentration on short-term outcome in patients with stroke treated with thrombolysis. Methods:A total of 108 patients with stroke were enrolled in the study. Demographics, laboratory data, and clinic data were collected. According to the modified Rankin scale (mRS) scores at discharge, the patients were divided into either a good outcome group or a poor outcome group. Multivariate logistic regression model were used to analyze the correlation between SUA and the prognosis of stroke. Results:There were 66 (61.11%) patients in the good outcome group and 42 (38.89%) in the poor outcome group. The patients’constituent ratios of the age [(62.21±10.25) years vs. (57.83±10.457) years;t=2.138, P=0.035], previous type 2 diabetes mellitus (40.48% vs.12.12%;x2=11.600, P=0.001), history of stroke (9.52% vs.9.09%;x2=4.366, P=0.037) and baseline NIHSS scores (median interquartile range) [10(7.75～12.00) vs.4(3～7.25); Z=5.537, P=0.000] were significantly higher than those in the good outcome group, while the patients’constituent ratios of the SUA levels [(323.119±87.869) mmol/L vs. (385.961±76.166) mmol/L;t=3.936, P=0.000] were significantly lower than those in the good outcome group. Multivariate logistic regression analysis showed that the increased SUA was an independent protective factor for short-term outcome in patients with stroke treated with thrombolysis [odds ratio (OR) 0.992,95% confidence interval (CI) 0.986～0.998; P=0.015]. Conclusion:The increased SUA is an independent protective factor for short-term outcome in patients with stroke treated with thrombolysis.