| Objective:To evaluate 125I seed strip joint biliary stent safety and efficacy of the treatment of malignant obstructive jaundice. Methods:55 cases of obstructive jaundice patients were randomly divided into two groups,28 cases treatment group (stent+125I particle -Pack) and 27 cases the control group (simple stent group).Both groups were under the DSA-guided percutaneous transhepatic biliary stenting via the line, while the treatment group 125I seed implantation to strip and biliary stents intramural. The indicators of liver function, postoperative complications, stent patency and survival were observed before and after the intervention. Results: the surgical procedure of 55 patients was successful together with the good position of stent and there was no stent shift problem. There were no any serious postoperative biliary complications, perforation, and bleeding. During the period of 3 and 6 months of post-operation, between two groups’indicators of serum total bilirubin, direct bilirubin, indirect blirubin, alanine aminotransferase, aspartate aminotransferase and bile acid, there were significant differences, (P<0.05). Postoperative patients were followed up for a year, and there were no shedding radioactive particles found. The median survival of treatment group was 8 months with 95% confidence interval of 6.1 to 9.9 months. In the control group, the median survival was 5 months with 95% confidence interval of 3.3 to 6.7 months. The difference was statically significant, (x2= 19.39, P<0.05).Conclusion:for the treatment of malignant obstructive jaundice,125I particle strip joint biliary stents can significantly improve stent patency and can prolong the survival of patients. |
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