Analyze The Diagnostic And Prognostic Value Of Urine Protein Level And Serum SFlt-1/PLGF Ratio In Patients Of Preeclampsia

Objective:1.To analyze retrospectively whether the severity of urine protein can be used as a prediction index of maternal and infant complications and outcome in severe preeclampsia patients.2.To detect serum markers of s Flt-1and PLGF in patients with hypertensive disorders complicating pregnancy,discuss the likely clinical use of s Flt-1/PLGF ratio in patients with preeclampsia.Methods:1.Retrospectively analyze of 200 cases of patients in our hospital from January 2011 to June 2014 with severe preeclampsia and follow up neonatal survival situation. According to urinary protein, cases were divided into mild proteinuria group and severe proteinuria group. Statistical analyze and compare the two groups of maternal complications and perinatal outcome.2.Select 50 cases of pregnant women with gestational age control, 30 cases of early onset preeclampsia, 58 cases of late onset preeclampsia, 25 cases of gestational hypertension(GH) patients which were hospitalized in our from March 2011 to October 2014. To detect the serum concentrations of s Flt-1 and PLGF, analyze the relationship between s Flt-1/PLGF ratio with neonatal birth weight To study the ratio as early onset severe preeclampsia diagnosis index using ROC curve analysis.Results:1.Statistical analysis of 200 cases show that comparing the incidence of mother complications besides ascites, such as placental abruption, impaired liver and kidney function and so on, there was no statistical difference in this two group. In terms of perinatal complications and outcome, the incidence of fetal intrauterine distress, neonatal asphyxia and perinatal death were not statistically different besides fetal growth restriction. But patients with ascites and fetal growth restriction its 24 hours urinary protein quantitative results had no statistical difference with no ascites and fetal growth restriction patients.2.The s Flt-1/PLGF ratio of early-onset preeclampsia patients is significantly higher than other groups and is negatively correlated with neonatal birth weight, the area under the curve is 0.975 when used as a diagnostic indicator. The s Flt-1/PLGF ratio of late onset sever preeclampsia is highter than late onset mild preeclampsia When the total number of maternal and infant complications is more, the s Flt-1/PLGF ratio is higher.Conclusion:1.The severity of proteinuria is no obvious related to complications and adverse pregnancy outcomes in preeclampsia.2.The ratio in preeclampsia patients can assess illness severity and poor prognosis. The diagnosis of early-onset severe preeclampsia high s Flt-1/PLGF light the importance of the ratio. Moreover the s Flt-1/PLGF ratio can be used to predict birth weight.