Expression And Significance Of TROP2 In The Non-muscle-invasive Bladder Transitional Cell Cancer

Objective:The aim of this study is to evaluate TROP2 expressions at the protein levels in the non-muscle-invasive bladder cancer(NMIBC) tissues and its correlation with clinical and pathologic characteristics of patients as well as its clinical significance in NMIBC.Materials and methods:1、112 patients enrolled in this study. They were divided into two groups: Group A: 83 patients of NMIBTCC; Group B: 29 patients of muscle-invasive bladder cancer(MIBC). Group C: 29 patients of normal bladder tissues as control group. We used immunohistochemical staining to detect the expressions of TROP2 in all slices.2、All dates were received χ2 test to evaluate the correlation of TROP2 scores with clinical and pathological variables.3、We used univariate, multivariate Cox regression model to analyze the dates to evaluate the association of tumor recurrence with TROP2 expression, clinical and pathological variables.4、We used Kaplan-Meier survival curves to evaluate the association of TROP2 expression with NMIBTCC patients’ total recurrence-free survival.Results:1、Our study showed that the expression of TROP2 was relatively higher in the group A(31/83 patients) compared with group C(0/29 patients)(p<0.001, Fisher test), and relatively higher in group B(19/29 patients) compared with group A(31/83 patients)(χ2=6.900, P=0.009).2、In group A, the expressions of TROP2 were relatively higher in Multiple tumor group(18/30 patients) compared with single tumor group(13/53 patients)(χ2=10.301, P=0.001); the expressions of TROP2 were relatively higher in high grade group(12/13 patients) compared with low grade group(19/70 patients)(p< 0.001, Fisher test); the expressions of TROP2 were relatively higher in concomitant CIS group(8/10 patients) compared with the other group(23/73 patients)(P=0.003, Fisher test).3、A univariate analysis showed that the recurrence of NMIBTCC related to tumor stage, tumor grade, carcinoma in situ and TROP2 expression(each p< 0.05, respectively). A multivariate analysis revealed that TROP2 expression might be an independent predictor of tumor prognosis in patients with NMIBTCC.4、Kaplan-Meier analysis showed that TROP2 expression was significantly associated with NMIBTCC patients’ total recurrence-free survival(log-rank test, p< 0.001, respectively).Conclusions:1、Our study suggests that the expressions of TROP2 are relatively higher in the tumor tissues compared with the normal tissues and related to multifocality, carcinoma in situ and tumor grade in the NMIBC tissues.2、The recurrence of NMIBC may relate to tumor stage, tumor grade, carcinoma in situ and TROP2 expression.3、The expression of TROP2 may play an important role in helping doctors to evaluate the development and pathogenesis of NMIBC. Therefore, it may represent potential biomarker to predict the NMIBC prognosis.