| Background: cancer pain(referred to as pain): usually refers to violent pain from tumor complicated, including process for the treatment of cancer by the occurrence of pain, were also evaluated for a cancer pain. The world health organization(WHO) statistics show that,the whole world has exceeded 76% of the tumor patients are experiencing varying degrees of pain in the patients with tumor, most painful and most unbearable symptoms of pain. The world each year about about ten million new cancer patients, some of them for about about six million cancer died, and this was in the midst of about fifty percent patients pain symptom of different level, at the end of seventy percent cancer patients with pain as the main symptom is more strong. Patients with tumors of the cancer incidence in our country reached more than fifty percent.Painless should be the most basic condition, basic human rights, but also the most basic requirements. The world health organization recommends three steps analgesic at present has been used usually as pain patients pain guidelines, while get the analgesic efficacy of these drugs in the clinic is relatively large, but also with the addictive, drug resistance and a series of adverse phenomenon,make its benefit is limited by the crowd[1]. In recent years, Traditional Chinese medicine for the treatment of cancer pain has its unique advantages, and has made great progress. Chinese medicine external treatment method is one of the common therapy of traditional Chinese medicine, it is through the physical muscular striae direct administration, absorption through the skin or mucosa permeability body, effect directly on the affected area, rapid the analgesia effect. Oral analgesic drugs because its are required to pass through the digestive tract, the efficacy of itself in the process of absorption will encounter many link inactivated effect, internal and some drugs can bring more serious side effects. Advanced cancer patients,the body the already extremely emptiness, cannot afford to further the method of attack, coupled with the long-term pain suffering injury, the pathology its characteristic decision if rely on oral drugs,treatment effect is not good, need to seek more open thinking. And Chinese medicine external treatment because its have the advantage of characteristics at this point is critical in terms of practical significance[2].Research purposes: 1) clinical efficacy evaluation of bergamot gold paste, observation of bergamot gold beta-endorphin in peripheral blood in patients with cancer pain(beta EP)concentration change; 2) through the study of general physical examination subjects, vital signs; Routine laboratory tests and the adverse reactions to evaluate its security; 3)evaluation through the research of the pain the extent of subjects, imaging examination and assessment with the quality life, change the dosage of analgesic drugs such as evaluation of its curative effect.Methods: select 70 cases of patients with pain into standard. This experiment,According to the random principle, controlled the distribution of the 70 cases of research objects grouped into treatment group and control group, 35 cases in every team. Western and Chinese medicine treatment group(group) : bergamot gold placard apply affected part,replace 1 every 48 hours(according to the condition two drugs can be intermittent 2-6 h), at the same time, according to the cancer pain treatment standards(2011 edition) "prescribed by the three steps analgesic symptomatic analgesia treatment principle; Control group(simple western medicine group) : strictly carry out the cancer pain treatment standards(2011 edition) " prescribed by the three steps analgesic principles for clinical analgesic therapy. After the termination of the experiment, two groups were observed in patients in remission degree of pain before and after treatment, the quality of life of the analgesic effect,the patch(KPS) score, tumor entity lesions, the dosage of analgesic drugs,nalgesia the onset time of continuous time; at the same time with eLISA method(ELISA) were detected before and after treatment of cancer patients peripheral blood level of beta endorphin, parallel within group, between group and analyzed statistically.The research results:1 prior to therapy, the two groups in age, sex, the original disease, pain degree,Karnofsky score, pain relief medicine the amount, outside week blood beta endorphin level etc.,are no difference of statistics, comparable.2 after the treatment2.1 the analgesic effect of pain: on the basis of WHO standard of curative effect evaluation and combined with VAS method for determination, the treatment group was 5cases, efficient in 26 patients; the control group of 1 cases were cured, In 17 patients effectively, through the contrast analysis there exist obvious differences between the two groups(p<0.05). In treatment group, pain remission rate was 88.57%, control group, pain remission efficiency is 51.43%.2.2 Of the patients life quality improving: treatment group 22 cases are markedly effective, efficient in 11 patients; control group 14 cases were markedly effective, efficient in8 patients, by comparison analysis showed a significant difference(p<0.05).2.3 in terms of dosage of analgesic drugs: this topic calculation before and after treatment in patients with oral daily amount of oxycontin, treatment group and control group patients medications. After the treatment, the therapy group with statistical drug dosage fewer than that of control group, that the patch topical analgesic drug dosage can reduce pain patients, then is a certain extent, reduce its adverse reactions, compared with analgesic drugs alone, more easily accepted by patients.2.4 analgesic effect time and sustainable aspects: the treatment group effect time 0.64 +/- 0.15 h, control working time 1.69 + /- 0.47 h; Treatment group effect sustainable time43.37 + /- 3.46 h, control group for time 9.59 + /- 1.62 h.After the comparative analysis, the results show that there are significant differences in two(p<0.05). Conclusion shows that gold bergamot post combined three steps analgesic drug effect time is shorter, The analgesia effect could be maintained for a longer period.2.5 security: in 70 patients before and after treatment to check general physical, vital signs, the three indices such as routine, electrocardiogram(ecg), the patch influence on three conventional no, the liver, renal function, electrocardiogram examination results have little effect, high safety.2.6 adverse aspects: through observation, constipation during treatment control group 5cases, dizziness in 3, Because has not presented treatment causes the heart, liver, kidney,blood system damage; Treatment group appeared mild skin allergy in 2 cases, the rest does not appear other bad reaction.2.7 In the tumor focus, while the clinical efficacy of the treatment group than in control group, however, through the comparative analysis of two were not significantly different(p>0.05).2.8 peripheral blood beta endorphin measurement value comparison: after the treatment of peripheral blood group in patients with beta endorphin level the flat before treatment significantly increased(p<0.05), the control group group therapy and compared obvious difference(p<0.05).Research conclusions: 1) the bergamot gold thread connection joint oxycontin oral treatment of cancerous pain, In the aspect of treatment and relief of symptoms of pain in patients with significant curative effect, can obviously improve the KPS score, The quality of life of the patients get a good improvement, improve the clinical effect of combined medication; 2) bergamot gold placard in treatment of cancer pain, To raise peripheral blood level of beta endorphin, thus, the real treatment and alleviate cancer pain role;3)Bergamot gold paste can significantly relieve the symptoms of patients with pain and,also has certain detumescence fights, shrink the tumor. 4) bergamot gold thread joint three steps analgesic drugs can effectively shorten the time of analgesic effect and extend the limitation of analgesia, In the incidence of adverse reaction and safety use three steps analgesic therapy is superior to pure. |
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