The Expression Of Plasma Pentraxin-3 In Patients After Stent Implantation And Its Impact On The Short-term Prognosis

Aims: To explore the expression of Plasma Pentraxin-3 in patients after stent implantation and Its impact on the short-term prognosis.Methods: The research objects included 113 patients who be hospitalized because of chest pain or chest discomfort and underwent diagnostic coronary angiography who was treated by percutaneous coronary intervention(PCI) from March 2013 to March 2014 in Department of Cardiovascular Diseases of the second affiliated hospital university of south china. According the endpoints of the PCI group, these patients were divided into two groups: MACEs and without MACEs group. plasma concentrations PTX3 was measured By enzyme-linked immunosorbent assay(ELISA).Patients were followed up for 12 months for major adverse cardiovascular events(MACEs). Then compare the difference of the levels of the PTX3 by Statistical analysis. The MACEs defined as cardiac death, nonfatal myocardial infarction(MI), emerging heart-failure and target vessel revascularization(TVR).All the data were statistically analyzed.Results: 1. The post-PCI plasma PTX3 levels were significantly higher at 24 h after PCI than pre-PCI(5.67士2.47 VS 4.36士2.21 P<0.001 P<0.05).2. The Patients with MACEs had higher post-PCI PTX3 levels compared with MACEs-free patients(6.57 士 2.42 VS 5.37 士 2.33 P<0.001).3. The Patients with higher post-PCI PTX3 levels(> 5.39 ng/m L) had a higher risk for MACEs than those with PTX3(< 5.39 ng/m L).4. The Post-PCI PTX3,c Tn I, multiple stents, and age but not high-se nsitivity CRP(hs CRP) were independently associated with the pre valence of MACEs after DES implantation.Conclusions: 1. The expression levels PTX3 in patients with coronary heart disease after PCI rises obviously.2.The post-PCI PTX3 may be a more reliable inflammatory predictor of MACEs in patients with coronary heart disease undergoing stent implantation than hs CRP.3. Measurement of post-PCI PTX3 levels could provide a rationale for risk stra-tification of patients with coronary heart disease after PCI.