Uighur Coronary Heart Disease Patients With Diabetes Mellitus And The Related Discussion Of CYP2C19 Gene Polymorphisms

Objective:Xinjiang uygur incidence of coronary heart disease patients with di abetes mellitus CP2C19 gene polymorphism analysis and related discussion, for indi vidualized drug therapy and drug genomics research provides the basis.Methods:P articipants included 200 uighurs in hospital patients, divided into pure coronary hea rt disease, coronary heart disease, diabetes mellitus group, detection in patients (ma le:141, female:59) CYP2C19 genotype. Index for the results to determine t test. single factor variance analysis and statistical analysis. Results:The study detected a total of 6 different genotypes of CYP2C19, three kinds of metabolic type, type f ast metabolism of EM (CYP2C19*1/* 1) 60.5%, metabolic type of IM (CYP2 C19* 1/* 2, CYP2C19* 1/* 3) 33.1%, slow metabolism type PM (CYP2C1 9* 2/* 2, CYP2C19* 2/* 3, CYP2C19* 3/* 3) 6.4%. Simple coronary h eart disease, coronary heart disease, diabetes mellitus group comparison in age, plat elet count, fasting glucose, and glycosylated hemoglobin is P values were 0.000,0. 008,0.000,0.000, etc., was statistically significant difference between the two com parison groups. Logistic regression analysis showed that after adjusting for age. gen der, hypertension and other traditional risk factors, glycosylated hemoglobin and pla telet count is an independent predictor of coronary heart disease (CHD).Conclusion: Uighur coronary heart disease, diabetes mellitus has correlation with CYP2C19 ge ne polymorphisms have been found...