Analysis The Correlation Between TGF-β₁-509-c/T Gen Polymorphism And TGF-β₁ Plasma Concentration And The Formation Of Intracranial Aneurysms In People With The Han And Uighurs

Objective:To observe the relationship of TGF-beta 1 concentration in plasma with intracranial aneurysm formation in Xinjiang uygur and han Chinese and to observe the relationship of TGF-β1gene-509-C/T polymorphism with intracranial aneurysms formationin Xinjiang uygur and han Chinese. Methods:Diagnosis of 120 cases of intracranial aneurysm patients as experimental group by DSA,60 patients with negative there sults of the tests in the same way as the controlgroup. Getting genomic DNA from the samples. Access to atargetsite of the bases, the MALDI-TOFMS method to determine where the base type. Elassa experiment isused to inspect each plasma concentrations of TGF-betal. Analysis of the differences between two groups of plasma concentration of TGF-betal. To explore the formation correlation of TGF-betal plasma concentration and xinjiang uygur and han intracranial aneurysm. Results:There is no direct relationship between TGF-β1gene-509-C/T polym or phismand intracranial aneurysm formation in Xinjiang uygur and han Chinese. May TGF-betal higher expression is associated with intracranial aneurysm. May TGF-betal higher expression in the ethnic difference sex is in the process of formation of aneurysm, bigger, rupture in patients with intracranial aneurysm. Conclusion:There is no direct relationship between TGF-β1 gene-509-C/T polymorphism and Intracranial aneurysm formation in Xinjiang uygur and han Chinese. After the rupture of intracranial aneurysms, TGF-betal protein expression-up. The Uighur patients’plasma protein concentration who’s intracranial aneurysm rupture are higher than the han nationality patients’.