Combined Detection Of C- Reactive Protein, Erythrocyte Sedimentation Rate And Procalcitonin On The Clinical Significance Of Early Postoperative Infection After Lumbar Operation

Objective:To explore the clinical significance of combined detecting serum C-reactive protein(CRP), erythrocyte sedimentation rate(ESR) and procalcitonin(PCT) regular level in the early diagnosis of infection after lumbar operation in different operating methods. Methods:Selecting 297 normal healing patients (non infected group) and 31 patients who occured postoperative surgical site infection (infection group) after lumbar operation in different operating methods,and comparing the different response of CRP, ESR, PCT preoperatively and on postoperative Days 1,3,5,7 between two groups. Results:The postoperative ESR, CRP level both in infection group and non infected group of patients with different operating methods is higher than preoperation;Within the infection group or non infected group of patients who accepted orthopaedic insertion have a higher-peak of ESR,CRP,PCT than patients without insertion.The ESR,CRP and PCT level in infection group of patients who accepted the same operation is higher than non infected patients;All of these differences were statistically significant(P<0.05).With the CRP>25 mg/L(CRP>46 mg/L patients who have internal fixation) at postoperative Day 3 in patients, ESR>45 mm/h,PCT>2.0μg/L at postoperative Day 5 as diagnostic standard,any index exceeds its critical value is the diagnosis of infection, three indicators did not reach the critical value is to rule out infection, then the sensitivity for diagnosis of early infection in patients after lumbar operation was 99%, and the specificity was 98%. Conclusion:Combined detecting serum CPR, ESR and PCT regular level have a high significance in the early diagnosis of infection after lumbar operationlevel,and CRP>25 mg/L(patients with insertion CRP>46 mg/L) at 3 days after surgery, ESR>45 mm/h, PCT>2.0μg/L at 5 days after surgery should be early consideration of postoperative infection positively.