The Study Of Vasculogenic Mimicry And Prognostic Factors In Lung Cancer Brain Metastasis

Abstract[Objective]Vasculogenic mimicry(VM) is involved in the process of tumor initiation and progression, particularly in angiogenesis. However, the prognostic significance of VM in lung cancer brain metastases have not been elucidated. In this study, we were trying to detect the presence of VM in lung cancer brain metastases and evaluate the role of VM in patient prognosis.[Methods]The clinical data(including age, gender, primary tumor location, grading, metastatic tumor location, tumor size metastasis, number, therapeutic strategy, degree of tumor resection, karnofsky performance status(KPS) scoring). were retrospectively reviewed in 60 patients with lung cancer brain metastases(from 2000 to 2014). CD34-PAS expression was analyzed by immunohistochemistry on tumor tissues.[Results]We found that elevated VM was primarily distributed in lung cancer brain metastases and the VM-positive incidence rate in brain metastases was 36.6%. The univariate analysis showed that KPS scoring, age and treatment strategy, but not VM, were related with survival time. The multivariate analysis indicated that KPS scoring and treatment strategy after surgery were closely related to patient prognosis.[Conclusion]VM exits in lung cancer brain metastases, but does not associate with patient prognosis. Longer survival of patient was related with KPS scoring(over 70) and treatment strategy after surgery.