The Protective Mechanisms Experimental Study Of Shunao Jieyu Soup In Post-stroke Depression Rats

Objective: To study the impact of sparse brain decoction on Post-stroke depression in rats and its possible mechanism of action.Methods: Zea-longa modified intraluminal focal cerebral ischemia-reperfusion model combines solitary custody and chronic unpredictable mild stress model of composite preparation PSD, PSD will be successful model rats were randomly divided into model group,Shunao Jieyu soup large, medium and small dose group, and paroxetine groups five groups of 15 rats in each group, plus a control group of 15 rats. Shunao Jieyu soup of large, medium and small dose group were gavaged of Shunao Jieyu soup(3.015/g.kg-1,1.058/g.kg-1,0.704/g.kg-1), paroxetine group paroxetine hydrochloride solution(0.0017/g.kg-1) gavage, the control group, the model group were given an equal volume of normal saline. Gavage 4 weeks, learning and memory abilities of rats. After the end of the administration, the rats decapitated line and detect brain pathology observed in the hippocampus of monoamine neurotransmitter content and GFAP protein expression.Results:Shunao Jieyu soup large dose group and paroxetine hydrochloride, can increase the weight and sugar consumption PSD rats, PSD shorten the immobility time of rats tail suspension and forced swimming immobility time, can significantly prolong the PSD big Mouse positioning navigation escape latency time, the target quadrant dwell time,increase the number of PSD rats through the platform, the goal quadrant dwell time ratio and the target quadrant run rate was statistically significant(P <0.05 or P <0.01), and can improve the PSD big hippocampal tissue 5-HT, DA, NE levels, reduce GFAP positive cells was statistically significant(P <0.05 or P <0.01). Pathological examination showed liver qi stagnation soup each dose group and paroxetine hydrochloride group could improve cell pathological damage hippocampus rats.Conclusion:Large dose of Shunao Jieyu soup can effectively improve the symptoms of depression in PSD rats, PSD to improve learning and memory in rats, PSD ratshippocampal tissue injury has a protective effect, the mechanism may be related to the increase in the rats brain single PSD amine neurotransmitter content and decreased hippocampal PSD protein expression in rat GFAP related.