| Objective:To evaluate the value of frozen section examination for diagnosis in the cervical lesions on patients with cervical intraepithelial neoplasm, and to compare the detection rate of frozen section examination between the LEEP conization and the cold knife conization.Methods:The 573 clinicopathological materials of cervical intraepithelial neoplasia patients who underwent conization biopsy in our hospital from Jan 2010 to Dec 2014 were analyzed retrospectively. The mean age of the patients was 38.07±7.78 years old and all of them were diagnosed of cervical intraepithelial neoplasia by Colposcopic Biopsy. According to their different surgery, we put them apart in two groups:the LEEP conization group and the cold knife conization group.Preoprative,intraoperative and postoperative pathological grade transformation and surgical treatment were analyzed.Results:①The accuracy of colposcopic biopsy diagnosis was 78%(446/573) (P<0.05), indicating that there was statistically significant difference between the colposcopic biopsy diagnosis and the permanent paraffin section analysis. ②.The accuracy of frozen section examination was 92%(480/522) (kappa=0.801,P>0.05), indicating that there was no statistically significant difference between the frozen section examination and the permanent paraffin section analysis. ③There was no statistically significant difference between the two groups with the detection rate of the frozen section examination.Conclusions:Frozen section examination is a rapid and reliable method for evaluating CIN specimens. United with Frozen section examination, the LEEP conization can be the first choice to diagnose and treat the patients with cervical intraepithelial neoplasm. |
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