Bullous Pemphigoid: A Case Report And A Review Of The Literature

ObjectionThe aim is to investigate the clinical manifestations, auxiliary examination Features of bullous pemphigoid (BP) and to improve the acquaintance of this disease,to decrease the rate of misdlagnosis and missed diagnosis.MethodsWe retrospectively analyzed the clinieal data of one case which is confirmed by Department of dermatology Shandong University Qilu Hospital, and reviewed foreign and domestic literatures. And gave a systematic exposition of the clinical manifestations, auxiliary exaxnination and pathological features, diagnosis and treatment of BP.ResultA 56-year-old man with a 2 month history of systemic erythema, blisters, itching for 2 months. Nissl syndrome was negative. The body scattered erythema, blisters, bullous tension, partial erosion, surface scab. Routine analysis of blood showed WBC 8.14x109/L, HGB 132g/L, RBC 4.05x1012/L. Biochemistry ALT 23U/L, AST 16U/L, ALB 31.9g/L, BUN 6.70mmol/L, Cr 62umol/L. Biopsy showed subepidermal blistering with a prominent neutrophilic infiltrate. A diagnosis of bullous pemphigoid was made. Treatment with systemic corticosteroids, and immunosuppressive agents was effective.ConelutionsBullous pemphigoid is a subepidermal bullous skin disease. It is common among older people. It is characterized by tension blisters in normal or inflammation of the skin, immune pathological examination at the epidermal basement membrane with linear deposition of IgG and C3. It needs identification with pemphigus, acquired bullous epidermal necrolysis, dermatitis herpetiformis and bullous diseases such as lupus erythematosus. Therefore, clinicians should raise the awareness of the disease and ensureearly deteetion, early diagnosis and early treatment.