| ObjectivesThe study was promoting blood circulation to remove blood stasis type of traditional Chinese medicine in the treatment of sepsis myocardial injury cases were retrospectively study, to explore the diagnosis and treatment of traditional Chinese medicine for activating blood circulation sepsis the clinical curative effect of myocardial injury, to explore the diagnosis and treatment of traditional Chinese medicine for activating blood circulation sepsis possible mechanism of myocardial injury.MethodsBetween January 2013 to May 2014, guangdong hospital of TCM intensive medicine were 387 cases of sepsis patients, in 60 patients with sepsis myocardial damage detection. Record the usage of traditional Chinese medicine, according to whether using promoting blood circulation to remove blood stasis drugs into huoxue group and the blood groups. To Chinese medicine dialectical sepsis patients with myocardial injury. Record sepsis myocardial injury of the patient’s age, gender, the number of damaged organs, the number of the infection, inflammation index, APACHE II score, MODS score, score of blood stasis syndrome, troponin, BNP, CK-MB, EF%, LVEDVI and LVESVI etc. ResultsThere are 60 patients with sepsis myocardial injury, traditional Chinese medicine using promoting blood circulation to remove blood stasis type of 30 patients (50.0%), qi and 19 cases (31.7%), qingrejiedu class 11 cases (19.3%); Blood group and control group,30 cases of blood group 30 cases; Average age (67.59 and 16.23),39 cases (65%) of men and women 21 cases (35%). The average number of damaged organs (2.45±0.37); The average infection site (1.68± 0.44); Basic qi deficiency syndrome of TCM syndrome in 41 cases (68.3%),38 cases (63.3%) of blood stasis syndrome, phlegm syndrome 28 cases (46.7%).1.7 days after treatment, blood group of the WBC, CRP and PCT concentration was decreased obviously, the difference is statistically significant (P< 0.05), the blood group of decline is not obvious; Invigorate the circulation and invigorate the circulation of group comparison differences statistically significant (P<0.05).2.7 days after treatment, blood activating group of APACHE â…¡ score, MODS score, score of blood stasis syndrome was significantly decreased, the difference is statistically significant (P<0.05), the blood group of decline is not obvious, invigorate the circulation and invigorate the circulation of group comparison difference was statistically significant (P<0.05).3.7 days after treatment, blood activating group of troponin I, BNP concentration was decreased obviously, the difference is statistically significant (P<0.05), the blood group of decline is not obvious, invigorate the circulation and invigorate the circulation of group comparison differences statistically significant (P<0.05); Two groups of CK-MB concentration decline is not obvious, there was no statistically significant difference between the two groups (P>0.05); EF% rise in blood group, LVEDVI and LVESVI fell, the difference is statistically significant (P<0.05), the blood group of EF% increase is not obvious, LVEDVI and LVESVI decline is not obvious, invigorate the circulation and invigorate the circulation of group comparison difference was statistically significant (P<0.05). ConelusionQi difficiency and blood stasis syndrome is the most often sepsis myocardial injury type witness; Kind of traditional Chinese medicine for activating blood circulation can improve sepsis patients, reduce the myocardial injury of PCT in patients with sepsis, troponin â… and BNP concentration, reduce the body’s inflammatory response and degree of myocardial injury; Improve the contraction of the heart (increase EF%, reduce LVESVI) and diastolic dysfunction (reduce LVEDVI); Reduce the APACHE â…¡ score, MODS score, score of blood stasis syndrome, etc., thus improving the overall situation of myocardial injury in patients with sepsis suggest promoting blood circulation to remove blood stasis drugs for sepsis myocardial injury has good therapeutic effect. |
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