The Reseach Of The Type And Characteristics Of The Drug Of Myatheina Gravis Based On Data Mining

ObjectiveAnalysis the information of literature basis by modern different doctor make a diagnosis and give treatment of myasthenia gravis,by using statistical analysis, data mining and other related technologies. Through the comprehen-sive collection medical record, and input data, form the database of myasthenia gravis,Statistical myasthenia gravis occur among age, sex, clinical classifi-cation,clinical symptoms and medication. Analysis of TCM syndrome classifi-cation,medicine the relationship between disease and drug use peer content of myasthenia gravis, sums up the law of TCM syndrome diagnosis and treatment of myasthenia gravis.Methods1.From the library catalogue and related database retrieval to modern basis or the literature about diagnosis and treatment of myasthenia gravis, according to include and exclude standards, collect each make a diagnosis and give treatment of traditional Chinese medicine experience with 177 cases of proven case of myasthenia gravis.2.Will the basis content is decomposed into the basic information such as age, gender and western medicine and TCM syndromes, symptoms and drug information such as diagnosis and treatment of traditional Chinese medicine,and entry information, establishing database of myasthenia gravis disease.3. The data pretreatment, including the data standardization, data measur-ement and data cleaning, etc.,to prepare for statistical analysis and data mining.4.Using SPSS statistical software for myasthenia gravis database in ge-nder,age,clinical symptoms, western medicine classification, commonly used traditional Chinese medicine, such as variable frequency of statistical ana -lysis, using the factor analysis and clustering analysis method to analyze the symptom information, summarizes myasthenia gravis syndrome classificati-on.5. Use SPSS software clementine data mining, using association rule algo-rithm to myasthenia gravis symptoms and the relationship between drug use and its analysis of the data mining, discusses related laws of diagnosis and treatment of myasthenia gravis in TCM.Results1. The frequency statistics results(1)Myasthenia gravis case male to female ratio of 1:1.16, with more women than men in patients.(2)The onset age, there are two peak, the first peak is 21-40 years old (42.9%),the second peak in 41-60 years old (25.4%).(3) The clinical classification type frequency distribution for the eye muscle type 64 cases, accounting for 36.1%, moderate body type 62 cases, accounting for 35.1%, mild systemic model 34 cases, accounted for 19.2%, late heavy USES in 5 cases,2.8%,35.1%;Severe radical in 11 cases, accounted for 1.2%, with muscle atrophy type in 1 case, accounting for 0.6%.(4)Common symptoms are drooping eyelids, limb weakness,fatigue,stay, diplopia,pale face, chew, muscle weakness, difficulty swallowing, etc. For tongue veins symptoms, pale tonguered tongue, tongue fat, moss thin white, pulse fine,pulse heavy are relatively more frequency symptoms.(5)Commonly used traditional Chinese medicine astragalus, atractylodes, licorice, Chinese angelica, codonopsis, radix bupleuri, cohosh, dried tangerine or orange peel.poria cocos.2. The cluster analysis resultsThe first category:including stay, loose stools,pale complexion,cold limbs, pale tongue, tongue fat, red tongue, thin moss, moss white and yellow moss, pulse heavy.The second category:including eye fatigue,diplopia,insomnia,pale tongue, pulse string.The third category including dizziness, angular, dry mouth, red tongue, moss thin, pulse number.The fourth category:including limb weakness, fatigue, less gas lazy words, chewing weakness, difficulty swallowing, drinking water choke, low voice HSS.3. The association rules analysis results(1) Limited dizziness, eye movements, diplopia, burnout, stay, loose stools, and drooping eyelids correlation is larger. Muscle impotent soft, chewing weakness, difficulty swallowing,low voice HSS and limbs weakness correlation is the largest. Burnout, limb weakness, stay, and tired, pale face, stay, diplopia, limb weakness, such as the main symptom combination closely associated with drooping eyelids.(2) Dangshen, astragalus, atractylodes, angelica, radix bupleuri, liquorice, cohosh has strong correlation. Cohosh and radix bupleuri with strong correlation.(3) Stay, burnout,pale face, ptosis, diplopia,limb weakness, pale tongue, moss, moss thin white, pulse fine, the symptom such as pulse heavy all have strong correlation with astragalus, atractylodes. Conclusion1. The syndrome characteristics of myasthenia gravis type certificate can be grouped into fou categories,weak spleen and stomach, liver and kidney deficiency, qi and Yin deficiency type, spleen kidney both deficiency type.2. The symptoms associated with a greater degree in the same organs related lesions. Ptosis, weakness is a common symptom of the disease, and other symptoms are basically evolved therefrom.3. This disease treatment to make up for in yiqi decoction, sijunzi decoction, the basic formula is given priority to, fill in beneficial gas, Yangju got stuck. Accompanied by spleen yiqi, the benefit of the liver and kidney. The other from liver extinguish wind breeze t2dm, town, invigorate the circulation of t2dm Angle using rhizoma ligustici wallichii, batryticated silkworm drugs. Astragalus, atractylodes two herbs in the treatment of myasthenia gravis as the main drug in the drug. Puerarin in the treatment of the disease have certain characteristics.