Association Between Rs2910164 Polymorphism Of MicroRNA-146a Gene And The Susceptibility Of Gastric Cancer:a Meta-analysis

Objective:To explore the association between a single nucleotide polymorphism (SNP) in rs2910164 of microRNA-146a (miRNA-146a) gene and the susceptibility to gastric cancer (GC).Methods:A computer-based online search was performed by using PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Data, VIP database and Wanfang database. The case-control studies associated between miRNA-146a rs2910164 polymorphism and the susceptibility of GC were selected according to the inclusion and exclusion criteria. After data extraction and quality evaluation, a Meta-analysis was performed by using STATA 12.1 software. Odds ratio (OR) and its 95% confidence interval (CI) were calculated. Then the subgroup analysis, sensitivity analysis and publication bias test were performed.Results:A total of 8 case-control studies were included in this Meta-analysis, including 4 308 cases and 6320 non-tumor controls. Meta-analysis showed that the miRNA-146a rs2910164 polymorphism was not signifiantly associated with the risk of GC in an allele model (C vs G) (OR =0.95,95% CI:0.84-1.08), additive model (CC vs GG) (OR=0.91,95% CI:0.71-1.16), dominant model (GG+CG vs CC) (OR=1.05,95% CI:0.85-1.29), recessive model (GG vs CC +CG) (OR=1.12,95% CI:0.94-1.34) and codominant model (CG vs GG+CC) (OR=0.95, 95% CI:0.88-1.03). Sensitivity analysis which excluded a study (from Okubo M, et al) showed that allele model and additive model were signifiantly associated with the risk of GC (OR=0.87, 95% CI:0.84-0.95; OR=0.80,95% CI:0.70-0.91). Subgroup analysis by Lauren’s type revealed that the recessive model (GG vs CC+CG) was associated with the increased risk of GC (OR= 1.24,95% CI:1.04-1.48).Conclusions:miRNA-146a rs2910164 polymorphism may be not signifiantly associated with the GC susceptibility.