A Research Of Magnesium Isoglycyrrhizinate Trerapy For Liver Lesion In Radiofrequency Ablation

Objective To explore the clinic effect of Magnesium isoglycyrrhizinate on the patients with primary hepatic carcinoma after radiofrequency ablation(RFA).Methods 139 cases with primary hepatic carcinoma patients with liver lesion by RFA were randomly divided to two groups : receive magnesium isoglycyrrhizinate therapy group(treatment group n=69) or conventional treatment group(control group n=70). Treatment group receive magnesium isoglycyrrhizinate 200 mg added in 250 ml 0.9% Nacl iv gtt qd from the right day to the 7th day after RFA operation. Control group receive diammonium glycyrrhizinate 150 mg added in 250 ml 0.9% Nacl iv gtt qd from the right day to the 7th day after RFA operation. Liver function will be test on preoperative and the 1st 、3rd 、7th day after RFA operation.Results The changes of index to reflect the liver lesion(ALT,AST):The levels of ALT and AST showed no statistically differences( P>0.05)before RFA operation between control group and treatment group. The levels of ALT and AST on the 1st and 3rd after RFA operation were significantly increased than those before RFA operation in treatment group( P<0.05).Compared with the level of ALT before RFA operation,the level of ALT on the 7th was significantly increased in treatment group(P<0.05). The levels of ALT and AST on the 1st、3rd、7th days were significantly increased than those before RFA operation in control group(P<0.05). The levels of AST on the 3rd day after the RFA operation、the ALT and AST on the 7th days after the RFA operation in treatment group were lower than control group(P<0.05). The changes of index to reflect the secrete and excrete function of liver(TBIL,DBIL): The level of TBIL and DBIL showed no statistically differences before RFA operation between control group and treatment group(P>0.05).The levels of TBIL and DBIL on the 1st、3rd and 7th days in treatment group showed no statistically differences compared with those levels before RFA operation(P>0.05). The level of TBIL on 7th day was lower than the 1st and3 rd days after the RFA operation in treatment group(P<0.05). The levels of TBIL and DBIL on the 1st day and 3rd day after RFA operation in control group were higher than those before RFA operation(P<0.05). Both TBIL and DBIL on the 7th day after RFA operation have no statistically differences compared with those before RFA operation in control group(P>0.05). But the levels of TBIL on 3rd and 7th days after RFA operation were lower than the 1st level after RFA operation( P<0.05). The changes of index to reflect the synthesis and reserve functions of liver(TP,ALB):The levels of TP and ALB were no statistically differences before RFA operation between control group and treatment group(P>0.05). The levels of TP and ALB on the 1st 、3rd and7 th days after RFA operation were lower than those levels before RFA operation in both control group and treatment group(P<0.05). The TP level on 7th day was lower than the level of TP on the 1st day after RFA operation in control group(P<0.05). The levels of ALB on 3rd and 7th were lower than the TP level on the 1st day after RFA operation in control group(P<0.05).Conclusion Patients with hepatic carcinoma after RFA operation can lead to liver lesion. Magnesium isoglycyrrhizinate can protect the liver function of the patients with primary hepatic carcinoma after RFA operation rapidly and distinctly.