The Need Of 0.1% Fluorometholone Eye Drops In The Treatment Of Seasonal Allergic Conjunctivitis

Objective:Investigate the need of 0.1% Fluorometholone eye drops in the treatment of Seasonal Allergic conjunctivitis (SAC).Method:Outpatients with clinic diagnosis of SAC in The First Affiliated Hospital of Guangxi Medical University in 2014 were randomly divided into A and B two groups by flipping a coin. Group A is for Emedastine Difumarate eye drops TID and Sodium Hyaluronate eye drops QID. There are 25 cases of 50 eyes, including 12 cases of male and 13 cases of female, age arranged 4 to 59 years old. Group B is for Olopatadine eye drops BID, Emedastine Difumarate eye drops TID and Sodium Hyaluronate eye drops QID. There are 22 cases of 44 eyes, including 13 cases of male and 9 cases of female, age arranged 3 to 79 years old. Compared the two groups of patients before treatment, there showed no significant difference in age, status and symptoms score. Daily follow-up of symptom scores was recorded after treatment for the patient, and for the patients who had been treated for 3 days but still failed to ease symptoms,0.1% Fluorometholone eye drops were applied, follow up until symptoms became better. Comparison items of the two groups included:symptom scores and sign scores after 3 days non-steroid eyedrops treatment; The rate of Fluorometholone eyedrops needed and the scores of the symptom and sign before treatment in those need and need not Fluorometholone eyedrops. The statistics methods comparing the two groups of age,sex and symptom scores and sign scores, the rate of need of Fluorometholone eyedrops, and symptom scores and sign scores before treatment were T test, chi-square test, chi-square test and T test, respectively. P value smaller than 0.05 meat difference significantly.Result:The symptoms of 72% of patients in group A and 81.8% of patients in group B relieved after three days of treatment, while 28% of patients in group A and 18.2% of patients in group B who did not relieve the symptoms after three days treatment were prescribed with 0.1% Fluorometholone eye drops twice per day. The 0.1% Fluorometholone eye drops applied rate in Group A and Group B had no significant difference (P=0.428). Most of patients in both groups(90.9%) can become much better with symptoms relieved after three days using the Fluorometholone eye drops twice per day. There had no statistical difference with symptoms scores、sign scores and aggregate scores in A and B two groups before treatment and after 3-day treatment (P is 0.635、0.757、 0.667, respectively). Neither the statistical difference was found in those scores in those patients need or need not the Fluorometholone eye drops before treatment in group A (P is 0.56、0.223、0.303, resptively)and (?) B (P is0.159、0.509、0.610, respectively).Conclusions:Most of the SAC patients can be relieved by application of Emedastine Difumarate eye drops only or Olopatadine eye drops combined with Emedastine Difumarate eye drops for three days. A small part of patients need short-term and low frequency application of 0.1% Fluorometholone eye drops. And for those patients, most of them(90.9%) can become much better by using 0.1% Fluorometholone eye drops for three days with BID frequency.symptoms scores and sign scores might not be helpful in the judgment whether the Fluorometholone eye drops needed in SAC treatmen.