Analysis The Pathogens Of Respiratory Tract And Risk Factors Of Infection In Neonates With Mechanical Ventilation

Purpose This thesis is to provide basis for clinical diagnose and treatment mainly by analyzing the pathogens of respiratory tract and risk factors of infection in neonates with mechanical ventilation.Method Collect clinical data of 61 high risk neonates with mechanical ventilation in neonatology of The Third Affiliated Hospital of Guangxi Medical University from July,2012 to October,2014 and analyzing the data by statistics methods.Result The positive rate of respiratory tract pathogen culture in neonates with mechanical ventilation is 65.6% which are mainly Klebsiella Pneumoniae (30.2%),Pseudomonas Aeruginosa (24.5%) and Staphylococcus Haemolyticus (17%), and Gram negative bacteria takes a large part of all the bacteria(73.6%). The occurrence rate of ventilator-associated pneumonia (VAP) is 50.8%, among which the positive rate of respiratory etiology is 90.3% and 71.8% Gram negative bacterium infection. The infection rate of ventilator-associated respiratory pathogens in VAP group is higher than non-VAP group. Univariate analysis indicates that gestational age, infection, the duration with ventilation and frequency of reintubation etc. have statistics significance on the positive culture of respiratory etiology (P<0.05), and no significance to it from the aspect of gender, nationality and the birth weight (P<0.05). The differences of between VAP group and non-VAP group on gestational age, birth weight, the duration with ventilator, the time stay at hospital and hospitality expenses have remarkable statistics significance(P<0.05).Conclusion The occurrence rate of respiratory tract infections of neonates with mechanical ventilation is high, Gram negative bacterium takes a large part of all the bacteria. The high risk factors of VAP are premature delivery, low body mass, infection, the duration with ventilation and frequency of reintubation. When the mechanically ventilated neonates are combining with infection, anti-infection should be based on antibiotics susceptibility and experience medication.