HPV Testing In Cervical Cancer, Breast Cancer Screening

Objective: 1. To investigate the diagnostic value of transvaginal ultrasound elastography in cervical cancer screening. 2. To explore the correlation between the degree of HPV infection and cervical ultrasound elasticity imaging performance. 3. The relationship between HPV 16, 18 infection and breast cancer was analyzed, with detection of HPV 16, 18 in benign and malignant human breast. The aim of the research is pursuing a better methods of cervical cancer, breast cancer screening.Methods: 1. A total of 92 cases of cervical lesions, examined them with transvaginal ultrasound and combined transvaginal ultrasound elastography respectively, the pathological findings as the gold standard, analyze the diagnostic value of the two methods in cervical cancer screening. 2. Patients diagnosed as cervical lesions who examined by combined transvaginal ultrasound elastography examination underwent cervical lesions hybridization assay II(HC 2) detection to analyze the correlation between all levels of ultrasound elastography scores imagines and cervical lesions human papillomavirus(human Papilomavirus, HPV) DNA load. 3. Selected the outpatient cases 100 cases of breast cancer screening, with pathological findings as the gold standard, using a case-control method, choosed 80 cases of breast cancer cases as the case group, 20 cases of normal mammary gland as a control group, all breast samples have been detected HPV16, 18 DNA with the polymerase chain technology(Polymerase chain reaction, PCR) and then all of the results were compared HPV 16, 18 positive rate.Results:1. Transvaginal ultrasound diagnosis of cervical malignancy sensitivity, specificity, and accuracy were 58.3%, 79%, 64.3%; combinedtransvaginal ultrasound elastography examination were 79.7%, 81.8%, 84.8%. Dimensional transvaginal sonography compared with both the joint inspection, the difference was statistically significant(2c = 4.12, P <0.05).2. The greater HPV infection load, the higher cervix by transvaginal ultrasound elasticity score.3. Breast organizational controls HPV16 positive rate was 10%(2/20), and the positive rate was 55.5% in case group(30/54). There are significant differences between the two groups(2? =12.341, P<0.000); Breast organizational controls HPV18 positive rate was 5.00%(1/20), and the positive rate was 18.51% in case group(10/54). There are significant differences between the two groups(2? =11.441, P <0.001).Conclusion:1. There is a high diagnostic value in cervical cancer screening by transvaginal ultrasound elastography.2. HPV infection and cervical load transvaginal ultrasound elasticity scores were positively correlated.3. There is a certain relationship between HPV 16, 18 infection and breast cancer.