Study Of Modified Zuoguiyin And Erzhiwan On Menopausal Syndrome Of Yin Deficiency Of Liver And Kidney

ObjectiveThis research in basic pathological characteristics of menopausal syndrome with liver and kidney Yin deficiency as a starting point, combining with the characteristics of geographical environment, climate in Taiwan, and in view of the menopausal transition common symptoms such as hot flashes sweat out, insomnia, forgetfulness, based on the kidney and nourishing Yin, the therapeutic principle of liver blood tonic, left to drink or two to prescriptions in traditional pill, on the basis of joining floating wheat yiqi stop sweat, tranquilize the lily, polygala calming nerves is strong. In order to achieve ziyin kidney, liver blood, calming nerves sedative effect, observe left to drink or Erzhiwan in patients with liver and kidney Yin deficiency type of menopause syndrome in clinical curative effect, explore left to drink or Erzhiwan action mechanism for the treatment of menopausal syndrome may exist.Methods:In March 2014 to November 2014 to Taiwan * * clinics, diagnosed with climacteric syndrome, and TCM syndrome differentiation in patients with liver and kidney Yin deficiency type, random select 60 patients were divided into control group and treatment group comparison research. Treatment group: rehmannia 9 g,9 g yam, medlar,9 g, poria cocos 6 g,6 g dogwood, main licorice 3 g, fructus ligustri lucidi 9 g,9 g dry lotus grass, floating wheat 15 g,9 g, lily polygala 6 g; Control group:fructus ligustri lucidi 9 g,9 g dry lotus grass, a dose of daily, morning and evening suit, even served two months. All preparation science and traditional Chinese medicine (TCM), a dose of daily, morning and evening suit, even served two months. Comparison before and after treatment, patients were followed up for a month kupperman score and TCM syndrome score improvement and serum FSH, LH, E2 levels.Results:1, the balance between groupsThis study adopts the method of randomized controlled trials for clinical trials, a total of 60 patients with closed qualified. Patients in treatment group and control group in age, course of diseases, Kupperman integral, TCM syndrome integral, serum endocrine level and so on, there was no statistically significant difference after two groups of data statistics, two groups of good balance, comparable (p> 0.05). Treatment group of 41 years old, the youngest biggest 53 years old; The shortest duration of 3 months, the longest 27 months. Kupperman before treatment to the total score of 34.87 and 3.52, TCM syndrome total score of 30.87 and 2.54, the average serum endocrine levels are 75.27 and 6.61 IU/FSH, LH,72.16 and 7.69 L IU/39.03 and 3.20 L, E2 pmol/L. Control the youngest 42,53 biggest; The shortest duration of 3 months, the longest 26 months. Kupperman before treatment to the total score of 35.40 and 2.86, TCM syndrome total score of 31.00 and 2.91, the average serum endocrine levels are 74.46 and 6.93 IU/FSH, LH,69.88 and 8.12 L IU/38.28 and 4.79 L, E2 pmol/L.2, compare before and after the treatment itselfBefore treatment group total integral Kupperman from treatment dropped to 34.8734.87,3.52 and 34.87, the integral in addition to the "item" has dropped significantly, the difference was statistically significant (p< 0.05); Control group Kupperman total score from treatment before dropped to 35.4035.40,2.86 and 35.40, the integral in addition to the "item" has dropped significantly, the difference was statistically significant (p< 0.05). Prompt left to drink Erzhiwans and use Erzhiwan can obviously improve the menopausal symptoms in patients with integral. The treatment group total score from treatment of syndromes before dropped to 30.87 30.87,2.54 and 30.87 ; Control group Kupperman total score from treatment before dropped to 31.0031.00,2.91 and 31.00, the integral has declined significantly in both groups, the difference was statistically significant (p< 0.05). The average serum endocrine treatment group after treatment was 50.79 and 7.96 IU/FSH, LH,47.97 and 5.47 L IU/L, 51.90 and 2.79 pmol/E2 L; Average serum hormone level in the control group after treatment is 55.78 and 7.73 IU/FSH, LH,52.32 and 8.67 L IU/49.93 and 1.90 L, E2 pmol/L, the two groups after treatment, FSH, LH was decreased significantly, the E2 was significantly increased, and the differences were statistically significant (p< 0.05).3, comparing the two groups after treatmentHot flashes in treatment group than the control group in improving patients sweating, anxiety, muscle joint pain, headache, palpitations, skin ant line feeling, dyspareunia and total integral Kupperman have more advantages, and in improving patients’insomnia, depression, dizziness, fatigue weakness, have similar effect both urinary tract infection. Treatment group than the control group in improving patients’baking hot perspiration, restless, palpitations froze and zhong, headache, two heart heat, vaginal dryness, forgetfulness, hands and feet dry, itchy skin, night to urinate more and have more advantages, TCM syndrome total integral in improving patients with dizziness, tinnitus, mouth dry dry throat, god fatigue, insomnia, much dream, depression, frequent urination urine have similar effect both red, dry stool. The treatment group significantly lower than the control group, FSH, LH, E2 is significantly higher than the control group, the difference was statistically significant (p<0.05).4, clinical curative effectBoth group total effective rate was 100%, the treatment group (27 cases were markedly effective, effective in 3 cases, control group 2 cases were markedly improved,28 cases effective, compare the difference was statistically significant (p< 0.05).5, follow-up results,5.1 compared with itselfTreatment group patients with insomnia, muscle pain, bone Kupperman total score, two eye dryness, insomnia, much dream, defecate dry and TCM syndrome total integral is just at the end of the treatment of serious, forgetfulness than when it was over, improve treatment, at the end of the rest of the program and treatment; Control group patients with hot flashes of sweating, insomnia, anxiety, muscle joint pains, Kupperman total integral, baking hot perspiration, restless, two eye dryness, insomnia, much dream, brothers heart heat, night to urinate, defecate dry, TCM syndrome total integral is just at the end of the treatment of serious, the rest at the end of the project effect and treatment.5.2 compared with two groupsPatients in treatment group than the control group in improving patients’hot flashes sweating, insomnia, anxiety, muscle joint pain, headache, palpitations, skin ant line feeling, dyspareunia, Kupperman total integral, baking hot perspiration, restless, palpitations froze and zhong, headache, two eye dryness, insomnia, much dream, forgetfulness, hand, foot and heart heat, vaginal dryness, itchy skin, night to urinate more and have more advantages, TCM syndrome total integral and in improving patients’ depression, dizziness, fatigue weakness, urinary tract infection, dizziness, tinnitus, dry mouth, dry throat, fatigue, depression, frequent urination urine red god have similar results, defecate is dry.Conclusion:Modified Zuoguiyin and Erzhiwan and used alone Erzhiwan can obviously improve patients with liver and kidney Yin deficiency type Kupperman integral, left to drink or Erzhiwan treatment of liver and kidney Yin deficiency in patients with climacteric syndrome (hot flashes than just use Erzhiwan in improving patients sweating, anxiety, muscle joint pain, headache, palpitations, skin ant line feeling, dyspareunia and total integral Kupperman have more advantages., Modified Zuoguiyin and Erzhiwan and used alone Erzhiwan can obviously improve patients with liver and kidney Yin deficiency type of TCM syndrome integral, left to drink or Erzhiwan treatment of liver and kidney Yin deficiency type of menopause syndrome patients than just use Erzhiwan in improving patient baking hot perspiration, restless, palpitations froze and zhong, headache, two heart heat, vaginal dryness, forgetfulness, hands and feet dry, itchy skin, night to urinate more have more advantages and TCM syndrome total score., Modified Zuoguiyin and Erzhiwan and used alone Erzhiwan can obviously improve serum hormone levels in patients with liver and kidney Yin deficiency type, Modified Zuoguiyin and Erzhiwan to improve the effect is more obvious., Modified Zuoguiyin and Erzhiwanto 4 balls forward curative effect than single use Erzhiwan more stable.