The Study Of Tongxinluo Capsule On Cognitive Impairment After Acute Stroke With Blood Stasis Symptom

ObjectiveProspective intervention on Tongxinluo capsule treatment of post-stroke cognitive impairment with blood stasis type, affect the cognitive function of patients’randomized, controlled clinical study.MethodsCollected 70 patients from March 2013 to September 2014 in Nanhai Hospital of traditional Chinese Medicine neurology, confirmed by imaging examination with acute ischemic stroke and with blood stasis of Chinese medicine dialectical, who met the inclusion criteria and exclusion criteria. Randomly divided into treatment group (Tongxinluo group) and control group (Idebenone group),35 cases in each group. Treatment groups:conventional western medicine treatment, add Tongxinluo capsule 3 pills once, three times a day for 12 weeks in a row. Control group:conventional Western medicine, add Idebenone tablets 30mg each time, three times a day for 12 weeks in a row. To collect and analysis the subjects of serum A β1-42 before and after treatment. Recorded the subjects of TCM syndromes, MMSE, MoCA, ADL and NIHSS scale score on the first day and 3 months. To make a detailed record of all data and its statistical analysis.Results1. No statistical significance of two groups’patients with blood stasis syndrome integral difference before treatment of TCM Syndromes. Comparison of the clinical curative effect of TCM syndrome after treatment, the treatment group were 34 cases,15 cases were significant effect (44.12% cases),14 cases were effective (41.18%), invalid in 5 cases (14.17%), the total efficiency of 85.83%; control group were 33 cases,6 cases were significant effect (18.18%), effective in 16 cases (48.48%), invalid in 11 cases (33.33%), the total efficiency of 66.67%.. Two groups of patients’TCM syndrome were improved after treatment, treatment group had a better efficacy than the control group, which showed a statistically significant difference between two groups (P<0.05)2. The two groups serum A β1-42 level change was statistically significant before and after treatment. After treatment, the two groups serum A β 1-42 were improved (P<0.05), which means Tongxinluo group and Idebenone group compared with no significant difference.3. Before and after treatment, the two groups MoCA cognitive scale scores were statistically significant change (P<0.05). After treatment, the two groups’ cognitive ability were improved, which meanes Tongxinluo group and idebenone group compared with no significant difference.4. The cognitive ability of two groups of patients with long-term follow-up were improved, no adverse reaction to medication.ConelusionTongxinluo capsule and Idebenone Tablets combined with conventional western medicine in the treatment of patients with cognitive impairment of cognitive function can effectively improve blood stasis after stroke, Tongxinluo Capsule on TCM syndrome and blood stasis syndrome improvement. Two groups of patients with good prognosis in the course of treatment, no adverse reactions. Serum A β1-42 levels and cognitive scale showed that the degree of cognitive function in patients with improvement are the same, and the serum A β1-42 concentration level detection is convenient, with intuitive data, available for clinical reference.