Investigation Of The Relationship Between Neuroendocrine Factors And Central Arterial Pressure And Peripheral Blood Pressure And Their Related Factors In Young College Students

Objective:Measurement of central systolic blood pressure(CSBP) by Sphygmo Cor non-invasive pulse analyzer in students, analysis of the relationship betwee n central systolic blood pressure and peripheral blood pressure; To investigate t he risk factors of central systolic blood pressure and peripheral blood pressure and the relationship between central systolic, peripheral pressure and neuroend ocrine factors.Methods:Using a non-invasive SphygmoCor pulse analyzer measurement centr al systolic blood pressure in students, with mercury sphygmomanometer to mea sure peripheral systolic blood pressure (SBP), diastolic blood pressure (DBP).The first chapter:To investigate the relationship between central systolic blood pressure and peripheral blood pressure and the risk factors of that. In ac cordance with the "guidelines for prevention and treatment of hypertension in China" (2010 Revision) systolic blood pressure more than 140mmHg and (or) diastolic blood pressure overtop 90mmHg and had a history of hypertension bu t is currently taking the blood pressure medicine blood pressure has dropped to normal, included 148 patients (127 males,21 females) of hypertension patients as case group, in accordance with the systolic blood pressure<140mmHg and diastolic blood pressure<90mmHg included 152 patients (118 males,34 femal es) as control group. Carries on the questionnaire survey, content includes basi c data, dietary habits, physical exercise, hypertension and other metabolic syndr ome family history and self rating Anxiety Scale (SAS), self rating Depression Scale (SDS) and Rosenberg self respect scale (SES). In the morning fasting c ollect venous blood. Blood routine, blood chemistries and C reactive protein(C RP) were determinedThe second chapter:Research center of systolic blood pressure and perip heral blood pressure and neuroendocrine factors. In accordance with the "guidel ines for prevention and treatment of hypertension in China" (2010 Revision) sy stolic blood pressure more than 140mmHg and (or) diastolic blood pressure ov ertop 90mmHg and had a history of hypertension but is currently taking the bl ood pressure medicine blood pressure has dropped to normal, into the young st udents’in 172 cases (male 151 cases, female 21 cases) of patients with hypert ension,198 cases (male 160 cases,38 cases of female) with normal blood pre ssure. a total of 370 subjects, aged 17-24 years old.The first part:the 172 cases of hypertension patients as case group,198 c ases of normal blood pressure as the control group, the analysis of central aort ic systolic pressure and peripheral blood pressure and angiolensin Ⅱ, aldostero ne, nitrogen monoxide and endothelin.The second part:The cases were divided into low (less than 23.99pg/ml), middle(24-63.99pg/ml), high (> 64pg/ml) three subgroup according to the cope ptin three quartiles, to analysis the relationship between the serum copeptin lev el and the central aortic systolic pressure, peripheral blood pressure and related factors.All statistical analysis using SPSS 16.0 software to complete, the measurem ent data with the mean standard deviation (x±s) said, count data case number (percentage) said. The difference of measurement data between groups of two groups were compared with t test, three groups were compared using analysis of variance and rank sum test, count data were compared using the χ2 test, si ngle factor linked by correlation analysis, continuous variables multiple factors analysis using multiple linear stepwise regression analysis,classification quantity multiple factors analysis using non conditional logistic stepwise forward regressi on. Test level alpha (a)=0.05, with P<0.05 as the difference had statistical sig nificance.ResultsThe first chapter:Central systolic blood pressure was significantly positive correlation with peripheral systolic, diastolic, mean arterial blood pressure, th e correlation coefficient (R) were 0.935,0.817,0.894, (P<0.01). Hypertension g roup and control group had no significant difference in age (P>0.05); heart rat e, arm around in hypertension group are significantly higher than the control g roup (P<0.01); the two groups of subjects of psychological factors with no stat istical difference (P>0.05). Hypertension group and control group of creatinine and urea nitrogen, blood platelet and white blood cells had no significant diffe rence (P>0.05); CRP, red blood cells and hemoglobin in hypertensive group w as significantly higher than that of the control group (P<0.01). Blood pressure is associated with body mass index, sports, family history of hypertension, hyp erlipidemia familial history, triglycerides and blood glucose(P<0.05). Another fa ctors, such as gender, sweets, salty food, sleep, smoking, drinking, tea, diabetes family history, overweight, family history and cholesterol had no significant as sociation with blood pressure.The second chapter:1. the plasma angiotensin Ⅱ, aldosterone and ET-11 evels were positively correlated with systolic blood pressure (SBP), diastolic bl ood pressure (DBP), mean arterial pressure (MAP) and central systolic blood p ressure (CSBP) (P<0.01). The level of serum nitric oxide was negatively correl ated (P<0.01) with systolic blood pressure(SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and central systolic blood pressure (CSBP).2. With the increased of copeptin level, peripheral systolic pressure, diastolic press ure, mean arterial pressure, central arterial pressure were increased gradually. C ompared with the lowest group,the highest group were 131.5+17.3mmHg,83. 73±12.2mmHg,95.86±13.6mmHg,115.24±14.2mmHg respectively, the lowest group were 124.8 ±15.2mmHg,79.05±10.1mmHg,91.02±11.5 mmHg,110.07 ±12.7mmHg respectively, the difference was statistically signif icant (P<0.01). Serum copeptin was positively correlated with central systolic b lood pressure (CSBP), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), body mass index, angiotensin Ⅱ, aldoster one, the correlation coefficients were 0.136,0.138,0.170,0.155,0.137,0.153, 0.220 (P<0.05),but it was negatively correlated with nitric oxide (r=-0.117, P =0.025).Conclusion:1, The young college students central systolic blood pressure was significantly correlaed with peripheral systolic pressure, diastolic pressure, mean arterial blood pressure.2, Some factors,such as sports, family history of hyper tension, triglyceride, glucose and BMI were important risk factors of young col lege students’elevated peripheral blood pressure. Triglyceride, glucose, BMI fac tors, and family history of hypertension were important risk factors of young c ollege students’central systolic blood pressure.3, Central systolic blood pressur e and peripheral blood pressure are correlated with angiotensin Ⅱ, aldosterone, nitric oxide and ET-1.4, the serum copetin level is not only related with the central systolic blood pressure and peripheral blood pressure, but also with the metabolic and biochemical indexes such as BMI, blood glucose and cholestero 1.