Observation On The Efficacy Of Tirofiban In Different Applications Of Emergency PCI In STEMI Treatment In Elderly Patients

Objective To observe the short term and long term effect comparison of Tirofiban in different applications of emergency PCI in STEMI treatment in elderly patients.Methods A total of 99 elderly patients with ST-elevation acute myocardial infarction who underwent primry PCI,were randomized into two groups.Fifty patients in groups A were treated with tirofiban by coronary injection+PCI.Forty-nine patients in groups B were treated with tirofiban by intravenous injection+PCI.All patients were treated with tilofiban by intravenous injection after emergency diagnosis.The two group in the emergency diagnosis were treated with tirofiban by intravenous injection.During the emergency PCI,the treatment group were given load of tirofiban by coronary injection after restoratinm of blood flow.The intravenous group were given PCI directly. The change of TIMI blood flow, myocardial perfusion grdading, corrected TIMI flame count(CTFC),degree of ST-segment recovey,left ventricular ejection fraction,major adverse cardiac events were compared between two groups.Results No difference was found in the TIMI blood flow between the two groups before PCI(P>0.05).TIMI3 fast-bloodflow in group A(86%)were significant superior to group B(69.39%)after PCI( P < 0.05).The myocardial perfusion grdading of group A(96%) was significant superior to group B(81.63%)( P < 0.05).CTFC, LVEF,degree of ST-segment fully-recovery after treament in group A were significant superior to group B(P<0.05).The comparison of the differences of the adverse events and the ruduce of PLT after operation were not signifidant(P>0.05).Conclusion Application of tirofiban by coronary injection in eldly patients with acute ST segment elevation myocardial infarction in emergency coronary PCI has more remarkable effect on the improvement of the heart function and myocardialmicrocirculation.