Research On Tissue Factor Expression Of Serum In Malignant Tumor With Pulmonary Thromboembolism

Objective:Based on the principle of thrombosis, the determination of Tissue factor (Tissue factor, TF) in malignant tumor with Pulmonary thromboembolism (Pulmonary thromboembolism, PTE) expression in patients with serum, Tissue factor is revealed in the diagnosis and treatment of malignant tumor merger PTE guidance value, discuss its become the diagnosis of malignant tumor with PTE markers, provide clinical guidance for the treatment of malignant tumor merger PTE.Methods:Collected in March 2012 to December 2014, the first affiliated hospital of Guang Xi medical university hospital diagnosis of malignant tumor with 30 patients with PTE (of 22 cases of lung cancer, gastric antrum carcinoma 2 cases,1 case of pancreatic cancer, intrahepatic bile duct carcinoma in 1 case, ovarian cancer 1 case, urachal carcinoma,1 cases sigmoid colon carcinoma in 1 case. Colorectal cancer 1 case), at the same time to collect 3 groups at random in the control group, respectively:59 cases of lung cancer alone (according to the pathological types are divided into small cell carcinoma of the 18 cases,25 cases of adenocarcinoma and squamous cell carcinomas in 16 cases, according to the smoking history divided into smoking history 38 cases, no smoking history 21 cases),49 cases of DVT, pure pure 57 patients with pulmonary embolism. By using enzyme-linked immunosorbent (ELISA) determination of groups of patients serum TF levels.Results:(1)Malignant tumor with PTE and pure lung cancer group, pure DVT, pure PTE group, the difference was statistically significant (P< 0.05). (2) simple lung cancer group, the comparison between pure DVT, pure PTE group, there were no statistically significant difference (P> 0.05). (3) malignant tumor with pulmonary embolism at high risk group compared with low risk group, the difference was statistically significant(P< 0.05). (4) with lymph node metastasis in tumor merger PTE compared with no lymph node metastasis, the difference was statistically significant (P< 0.05). (5) simple in lung cancer group, compared with non-small cell carcinoma, small cell carcinoma was statistically significant difference (P< 0.05). (6) simple adenocarcinoma and squamous cell carcinomas in lung cancer group, the difference was statistically significant (P< 0.05). (7) pure in lung cancer group, has a history of smoking compared with no smoking history, there was no statistically significant difference (P> 0.05).Conclusion:1. The tissue factor expression in malignant tumor merger PTE is higher than pure lung cancer group, the pure DVT, pure PTE group.2. Tissue factor expression in malignant tumor merger PTE different stratification, high-risk group is higher than the low risk group; With lymph node metastasis than without lymph node metastasis group; Express no difference in gender.3. The tissue factor in pure expression in lung cancer group, small cell carcinoma was higher than non-small cell carcinoma, and in non-small cell carcinoma, its expression in adenocarcinoma than squamous carcinoma. In the presence of smoking history express no obvious difference in the group.