The Clinical Analysis Of Effects Of Gestational Diabetes Mellitus On Maternal And Neonatal Delivery Outcome

Objective To investigate delivery-related outcomes and affected factors between gestational diabetes and non-diabetic both in mothers and neonatals.Methods A retrospective study of maternal and neonatal clinical datas was conducted in pregnant women who were diagnosed gestational diabetes and deliveried from October 2012 to October 2013 in the First Affiliated Hospital of Guangxi Medical University, including the cases adopting vaginal delivery and cesarean section, randomly selecting non-diabetic women in the same period as a control group. Comparison of two groups of maternal general informations、 FBG、75g-OGTT(1hPG、2hPG)、prenatal BMI and complications of maternal and neonatal after childbirth. Regressively analyzing related influenced factors, and looking through the ROC curve predicted cut-off point.Results GDM group and non-diabetes group had 185 and 196 cases included, respectively. The incidence of gestational hypertension of GDM group, prenatal BMI,the cesarean section rate, length of hospital stay was significantly higher than non-diabetic group. Meanwhile, compared with non-diabetic women, the age of newborns in GDM group was less, neonatal risk of multiple complications, the proportion of neonatalogy hospitalized was significantly higher. OGTT 2hPG and gestational age of the newborn may have predictive value for neonatal multicomplications, appropriate diagnostic cut-off point are 7.84mmol/L (area under the curve 0.613,95% CI:0.552-0.674, P=0.000) and 37week (curve under the area 0.649,95% CI:0.590-0.708, P=0.000).Hazards regression analysis showed OGTT 2hPG≥7.84mmol/L(OR value is 1.899, 95%CI:1.158-3.112, p=0.011), gestational age≤37 week(OR value is 3.699, 95%CI:2.019-6.778, p=0.000)were risk factors for neonatal multicomplications.Conclusion Gestational diabetes mothers and infants have significantly increased incidence of complications than the control group. In late pregnancy OGTT 2hPG≥7.84mmol/L made the risk of neonatal multicomplications 1.899 times increased, gestational age≤37 week, made the risk of neonatal multicomplications 3.699 times increased.