The Efficacy And Safety Of Mycophenolate Mofetil For Idiopathic Membranous Nephropathy:A Systematic Review Of Meta-Analysis

Purpose:The result of immunosuppressive therapies is controversy at home and abroad. This study aims to evaluate the curative effect and safety of mycophenolate mofetil for the treatment of idiopathic membranous nephropathy by a system review of meta-analysis.Method:The Cochrane Library, PUBMED, Web of Science, CBM, CNKI, VIP, WANGFA DATA were searched to identify RCTs investigating the efficacy and safety of mycophenolate mofetil for the treatment of idiopathic membranous nephropathy. The last research time was March,2015. Strictly according to the inclusion criteria and exclusion criteria screening of literature, and meta-analysis was conducted by using RevMan 5.2 software.Results:A total of 8 RCTs was included, involving 353 patients with idiopathic membranous nephropathy. The results of meta-analysis showed that there were no significant differences in any of the considered outcomes of mycophenolate mofetil+corticosteroids over alkylating agents+corticosteroids [RR=1.21(1.00,1.47), P=0.17].Conclusion:There were a similar efficacy between Mycophenolate mofetil plus corticosteroids versus alkylating agents plus corticosteroids. But the safety of Mycophenolate mofetil plus corticosteroids show superiority over alkylating agents plus corticosteroids.