| Objective: Diabetic nephropathy(DN) is one of the most common and severe microvascular complications of diabetes mellitus(DM), and it has become the second largest cause of end-stage renal disease in china. And it could cause great burdens to national economics, health care system and patients or their families. But to this day, though some reports showed that good controlling of blood gloucose, blood pressure, blood lipid and application of angiotensin-converting enzame inhibitors or angioensin receptor blockers might delay the discase progression, there is no effective therapy to cure or prevent the progression of DN. Bailing capsule is refined from cordyceps sinensis by low-temperature fermentation. It could improve the immunity of patients and expand blood vessels, strengthen blood circulation, decrease blood pressure, and then reduce 24 hour urine protein quantity, to achieve stable renal function and anti-renal failure effect.The purpose of the study is to investigate the changes of general clinical, renal function, blood glucose and blood fat-related index of patients with DN to evaluate the curative effects of bailing capsule in DN. So that we may be offer some new and useful clinical data for treatment of DN.Methods: 60 cases of DN patients who were hospitalized at Cangzhou People’s Hospital were randomly divided into two groups: 28 cases in control group, 32 cases in treatment group. The patients are in line with the 1999 WHO diagnostic criteria for DM and DN. All patients were diagnosed Ⅲ and Ⅳ period of DN according to Mogensen diagnosis standard tage. All the subjects eliminate eliminate diabetes complicating renal deseases and renal injury who not suffer from DM. Eliminating tumor, phlogosis and other influential factors. Patients in control group received diabetes proper exercise, diet control, and so on. At the same time, they were treated with irbesartan 150 mg once daily for 12 weeks. Patients in treatment group were treated with bailing capsule 3.0g three times daily for 12 weeks based on above-mentioned treatment. In the beginning, all the subjects were measured in terms of Height, Weight, duration of diabetes(DUR), body mass index(BMI), systolic blood pressure(SBP) and diastolic blood pressure(DBP). The overnight fasting(fasting≥12h) venous blood were extracted before and after the application of drugs to test fasting plasma glucose(FPG), 2 hour postprandial blood glucose(2h PG), glycosylated hemoglobin(Hb A1c), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), triglyceride(TG), C-reactive protein(CRP), Cystatin C(Cys C), homocysteine(Hcy), blood urea nitrogen(BUN), Serum creatinine(Scr). 24 hour urine were collected at the state of absent severe exercise before and after the application of drugs to detect urinary albumin excretion rate(UAER), urinary albumin(UALB) and β2-microglobulin(β2-MG). Comparising the treatment effect of renal function between two groups. Statistical analyses were done with SPSS Software(V13.0, SPSS Inc., USA). Measurement data were expressed as means ± s. Comparison between groups of measurement data used Student’s t-test. Count data were expressed used percentage. Comparison between groups of enumeration data used χ2 test. Statistically significant differences sets P<0.05.Results:1 Comparison of gender constituent ratioThe differences of gender constituent ratio between treatment group with control group were not statistically significant(P>0.05).2 Comparison of general clinical indexThe differences of age, DUR and BMI between treatment group with control group were not statistically significant(P>0.05).3 Comparison of blood pressure before and after administrationThe SBP of treatment group and control group decreased when compared to that before administration, the difference was statistically significant(P<0.05); and SBP of treatment group after administration decreased when compared to that before administration, the difference was statistically significant(P <0.05); However, The DBP of treatment group and control group compared to that before administration, the difference was not statistically significant(P>0.05); and DBP of treatment group after administration compared to control group after administration, the difference was not statistically significant(P >0.05).4 Comparison of FPG, Hb A1 c, 2h PGThe FPG, Hb A1 c, 2h PG of treatment group and control group decreased when compared to that before administration, the difference was statistically significant(P<0.05); and FPG, Hb A1 c, 2h PG of treatment group after administration decreased significantly when compared to control group, the difference was statistically significant(P<0.05).5 Comparison of TC, TG, LDL-CThe TC,TG,LDL-C of treatment group and control group decreased when compared to that before administration, the difference was statistically significant(P<0.05); and FPG, Hb A1 c, 2h PG of treatment group after administration compared to control group, the difference was not statistically significant(P>0.05).6 Comparison of CRP,Cys C, HcyThe CRP, Cys C, Hcy of treatment group and control group decreased when compared to that before administration, the difference was statistically significant(P<0.05); and CRP, Cys C, Hcy of treatment group after administration compared to control group, the difference was not statistically significant(P>0.05).7 Comparison of UAER, BUN and ScrThe UAER, BUN and Scr of treatment group and control group decreased when compared to that before administration, the difference was statistically significant(P<0.05); and UAER, BUN and Scr of treatment group after administration compared to control group, the difference was not statistically significant(P>0.05).8 Comparison of UALB and β2-MGThe UALB and β2-MG of treatment group and control group decreased when compared to that before administration, the difference was statistically significant(P<0.05); and UALB and β2-MG of treatment group after administration compared to control group, the difference was not statistically significant(P>0.05).9 Comparison of curative effectsTotal effective rato and obvious effect rato of treatment group was significantly higher than control group, the difference was statistically significant(P<0.05).Conclusions: Bailing capsule can decrease SBP and PG, improve the metabolism disorder of lipid, decrease the levels of CRP, Hcy and Cysc, decrease UAER, protect renal function and delay the progression of DN. Bailing capsule was deserved to generalization at clinical. |
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