Correlation Between Kidney Estimated Glomerular Filtration Rate And Clinic Pathology Of Idiopathic Membranous Nephropathy

Objective:To analyze the correlation between eGFR and clinico-pathological features of idiopathic membranous nephropathy (IMN) in151adult patients. Method:A Total of151patients of biopsy-proven IMN in Xinjiang Autonomous Region People’s Hospital from January2008to August2013were divided into normal renal function group and dysfunction group.Estimated glomerular filteration rate(GFR) was calculated according to MDRD equation, renal dysfunction was defined as eGFR<90ml·min-1·(1.73m2)-1, normal renal function was defined as eGFR:90～120ml·in-1·(1.73m2)-1.clinical features,labortery and pathology features were analyzed. Results:Of the151IMN patients (98males and53females,mean age42.88±13.14years)involved,126(83.4%) had nephritic syndrome,65(43.05%) had,32(21.19%) had hematuria.Compared with normal function group, renal dysfunction group had higher age, more hypertension,lower hemoglobin, higher urine IgG and higher score of glomerular sclerosis, focal segmental glomerular sclerosis, renal tubular interstitial (P<0.05),Age, high blood pressure, hemoglobin were considered as independent risk factors for the decline of renal function, OR (95%CI) were1.084(1.039～1.131),2.785(1.091-7.106),0.968(0.947-0.990).(P<0.05).Conclusion:IMN patients with hypertension and lower hemoglobin at presentation, accompanied by increased urine IgG, higher score of focal segmental glomerular sclerosis, renal tubular interstitial injury and renal glomerular sclerosis progressed quickly, patients with such clinic-pathological characteristics were considered as high-risk groups, had poor prognosis, should be treat as early as possible.