Research Of Association Between Senile Calcified Valve Disease And Osteoporosis

Objective:The aim of this study was to discuss the relationship between senile calcified valve disease (SCVD) and osteoporosis (OP). At the same time, we explore whether there are differences about SCVD in different genders and its correlation factors.Methods:A total353patients (male215,mean age72.09±7.73years; female138, mean age69.54±6.59years) were enrolled in this study, using transthoracic echocardiography to assess heart valve, according to SCVD diagnostic criteria, we divided all subjects into SCVD group (men57and women47),and non SCVD group (men158,women91); everyone’s bone mineral density (BMD) was measured with dual-energy X-ray absorptiometry. Assess lumbar spine, total hip and femoral neck bone mass Results:(1) The comparision of constituent ratios of osteoporosis in SCVD group and non SCVD group was statistically significant difference (χ2=21.698, P<0.05).And no matter male or female, the comparison between two groups, has statistical significance difference (male:χ2=11.775, P<0.05; female:χ2=7.532, P<0.05).(2) SCVD group patients, lumbar spine, and total hip T scores were lower than that of non SCVD group, there was statistically significant difference (t=1.984, P<0.05;t=2.938, P<0.05), the lowest T scores compared between the two groups, there is statistically difference ((t=2.904, P<0.05).(3) According to different gender subgroup analysis, comparison in SCVD group and non SCVD of female total hip T score, the difference was statistically significant(t=2.613, P <0.05),comparison of minimum T score, was statistically significant difference(t=2.274, P <0.05).SCVD group and non SCVD group of male, the comparison of lumbar spine, total hip, femoral neck T score, the difference was not statistically significant (P>0.05), the lowest T score comparison between the two groups, also has no statistically significant difference (t=1.415, P>0.05).(4) After multivariate logistic regression analysis, whether male or female, SCVD group compared with non SCVD group, osteoporosis was one of SCVD independent risk factors(male, OR:0.160,95%CI:0.043-0.596, P<0.05; female, OR:0.415,95%CI:0.195-0.881,P<0.05).(5)After multivariate logistic regression analysis, whether male or female, SCVD group compared with non SCVD group, age was one of SCVD independent risk factor, But there is no statistically significant difference in gender, hypertension, hyperlipidemia, diabetes.(OR:1.053,95%CI:1.006-1.102,P<0.05; female, OR:1.067,95%CI:1.008-1.130,P<0.05). Conclusion:(1) No matter male or female, SCVD group of osteoporosis the proportion is higher than non SCVD group. Speculated that osteoporosis may be associated with the onset of SCVD.(2) osteoporosis was one of SCVD independent risk factors, there is a certain correlation between osteoporosis and SCVD, bone mass reduction may be involved in the occurrence and development of SCVD.(3)Age was one of SCVD independent risk factors, as the growth of the age, SCVD may have a growth trend. It cannot be controlled because of the age, so we should strengthen the elderly health education, early detection and early treatment.