The Anti-C1q Antibody In Kidney Tissue And Its Value Of Judgment Of The Lupus Nephritis Disease Activity

Objective:To study the anti-C1q antibody (C1qAb) of kidney tissues in patients with lupus nephritis (LN) correlation of renal damage with systemic lupus erythematosus (SLE) and relationship with the autoantibodies such as AnuA、anti-dsDNA antibodies、ANCA、 ANA and anti-Sm on lupus nephritis disease activity;combined with other active index;alone or joint detection value in the diagnosis of lupus nephritis;anti-C1q antibody in different histopathological classification of lupus nephritis, relations of different levels of anti-C1q antibody with lupus nephritis disease activity.Method:Detection129patients who underwent renal biopsy were divided into two groups:the anti-C1q antibody positive group (n=64) and anti-C1q antibody negative groups (n=65) according to whether any anti-Clq antibody, at the same time record the various clinical manifestations of patients with systemic lupus erythematosus (SLE), to detect other autoantibodies (nucleosome antibody、antinuclear antibodies、anti dsDNA antibodies, antibody of neutrophils) and related laboratory index (blood counts, blood sedimentation, complement and quantitative24hours urinary protein, renal function, etc.).Results:Anti-C1q antibodies has no relevance with age、course of the disease、blood sedimentation、serum globulin、serum urea nitrogen、serum creatinine.has showed a negative correlation With complement C3、 C4、hemoglobin、serum albumin;has positive correlation with quantitative rate of glomerular filtration and24hours urinary protein, triglyceride, SLEDAI score.There are have consistency With anti-dsDNA antibodies、anti-Sm antibodies、antinuclear antibodies、 nucleosome、anti neutrophil antibody these five kinds of autoantibodies.Anti-C1q antibody score has a significant positive correlation with the SLEDAI score, Al.anti-C1q antibody expression in Ⅲ and Ⅳ type higher than other type, and it is considered strong activity.The increase of the degree of positive, the more active. Anti-serum complement of C1q antibody (++) group patients were significantly reduced;patients with Anti-C1q antibodies (+++) group have heavier low complement, and SLEDAI score and AI score increase gradually, gradually decline rate of glomerular filtration, more risk of renal impairment.