The Clinical Study Of Xijiaodihuangtang, Sij Unzitang Refractory Hepatitis C

Objective:To observe the xijiaodihuangtang,sijunzitang on the clinical efficacy of refractory hepatitis C, and compared with pegylated interferon and ribavirin and hepatoprotective western medicine to discuss the cooling blood detoxification, circulation tonic treatment of refractory hepatitis C viral response, changes in liver function and symptom improvement, evaluation of the advantages of the method for the treatment of refractory hepatitis C.Methods:Positive drug cohort study using the method according to the standard of refractory hepatitis C patients enrolled50patients in the treatment group22cases,25cases of the control group. Treatment group to xijiaodihuangtang,sijunzitang France prescriptions of traditional Chinese medicine treatment, the control group received pegylated interferon and ribavirin or liver medication, treatment for48weeks. Were observed in patients before treatment48weeks of treatment the comprehensive effect, antiviral efficacy, symptom treatment, symptom scores, liver function and safety indicators to compare the therapeutic effect of the two drugs.Results:A total of47patients completed48weeks of treatment, the treatment group of24ases, the control group of23patients. Treatment group,1patients lost to follow and fall off, the control group,2patients due to adverse events off without removing the case. After48weeks of treatment, clinical efficacy compared to the48weeks after treatment efficacy as follows, the treatment group markedly effective, efficient, the total efficiency of4.2%、83.3%、87.5%. Control group, significant efficiency, efficiency, total effective rate was30.4%、34.8%、65.2%, and the efficacy of the treatment group and control group showed no significant difference (p<0.05).Adverse reactions throughout the study does not appear.Conclusion:This study found that xijiaodihuangtang,sijunzitang improve the patient’s clinical symptoms and signs of circulation tonic treatment of refractory hepatitis C has obvious advantages. Treatment of traditional Chinese medicine and Western medicine treatment in reducing the level of ALT and AST was no significant difference in a short period of time, but can have a significant effect, reduce the degree of liver damage slow down the process of liver fibrosis. Chinese medicine treatment antiviral activity does not have a statistically significant difference compared to Western medicine antiviral effect, there is a certain gap. The long efficacy is an indispensable condition to be treated. Studies have shown that does not appear in the course of treatment of traditional Chinese medicine in patients with adverse reactions to significant bone marrow suppression, Western medicine treatment group the majority of patients with bone marrow suppression, Chinese medicine treatment of high security.