The Influence Of Low Intensity Ultrasound On Prostagllandin And Arginine Vasopression Of Uterus In Dysmenorrhea Model Of Rats

Objective To study the mechanism of low intensity ultrasound ondysmenorrhea.Methods45numbers of3-months-old rats (sexual maturity, unmated,female) randomly divided into normal group, model group and ultrasoundradiation group (each12). Estradiol valerate and oxytocin were used tobuild the dysmenorrhea model of rats. The rats in the normal group weretreated with normal saline. Then, the rats in the ultrasound radiation groupwere treated by Low-intensity Ultrasound (200kHz，0.2W／cm2) for10min,and those in the model group were received sham treatment. The writhingbehavior of rats was observed in20minutes after treatment. And the levelsof prostaglandin F2α (PGF2α), prostaglandin E2(PGE2) and argininevasopression (AVP) in uterus tissue were detected respectively.Results In ultrasound radiation group, times of writhing and totalscore were all significantly decreased (P<0.05). The level of prostaglandinF2α (PGF2α) and arginine vasopression (AVP) in uterus tissue were significantly decreased (P<0.05). While the level of prostaglandin E2(PGE2) was significantly increased (P<0.05), and the ratio of PGF2α/PGE2was decreased (P<0.05).Conclusions The pain in dysmenorrhea model of rats could be treatedeffectively by low intensity ultrasound by regulated the level ofprostaglandins (PGs) and arginine vasopression (AVP).