Dexmedetomidine Anesthesia Clinical Value On Emergence Agitation In Children In The Prevention Of Sevoflurane

Objective:To study the effect of sevoflurane for emergence agitation and safety of tonsillectomy of children, to observe the influence on the index of recovery quality children circulatory system, respiratory system, recovery time, postoperative and the effectiveness and safety of sevoflurane sedation for further evaluation.Methods:ASA grade undergoing tonsillectomy adenoidectomy80patients as the research object for the class I and class II. according to the different ways of anesthesia maintenance, children were randomly assigned into four groups:group C (sevoflurane), group D1(sevoflurane and dexmedetomidine with0.25μg/kg/h), group D2(sevoflurane and dexmedetomidine with0.5μg/kg/h) and group D3(sevoflurane and dexmedetomidine with1μg/kg/h). Children were induced by midazolam, fentanyl and propofol, intubationed with cistracurium. Ventilated and keep PETCO2from30to35mmHg. Patients were observed in the time before induction(T1), drug intravenous infusion before (T2), intravenous infusion of10min (T3),20min (T4),30min (T5), after the end of operation (T6) of HR, MAP, SPO2, ETCO2,, recovery time, operation time, recovery period of record with agitation and pain score.Result:1. There were no significant differences in general conditions among the groups(P>0.05).2. There were no significant differences in g MAP、HR、SPO2、 ETCO2and BIS among the groups(P>0.05). 3.Dexmedetomidine decreased the needed of sevoflurane in T3(P<0.05); at T4, Dexmedetomidine dose-dependently decreased the needed of sevoflurane (P<0.05);at T5,there was no difference on the concentration of sevoflurane between group C and group D1, the concentration is lower in group D2and D3than group C (P<0.05).4.The duration of awake, extubate and the time leave the PACU was prolonged in group D3compared to other groups (P<0.05). There was no difference on the pain scores in the groups (P>0.05). The mergence agitation scores were lower in group D2and D3than group C (P<0.05).Conclusion:Dexmedetomidine with0.5μg/kg/h could relieve the agitation caused by sevoflurane and have no effects on recovery time.