The Effect Of Fish Oil On Nutrition Improve And Immune Status Of Patients With Gastrointestinal Tumor After Operation

AIM To investigate the influence of a short infusion course of fish oil-based (ω-3)(study group) vs conventional (ω-6) lipid emulsion(control group) on modulating immune status and nutrition improve in patients of gastrointestinal tumor.METHODS Sixty-two gastrointestinal cancer volunteers requiring parenteral nutrition were randomized to receive an ω-3lipid emulsion(study group) rich in eicosapentaenoic(EPA) acid and docosahexaenoic(DHA) acid or a conventional (ω-6) lipid emulsion(control group) for5days. Blood samples were gained on the morning of day1, on the morning of day3and day6after operation respectively to measure HLA-DR, albumin(ALB), prealbumin(PA), total protein(TP), transferrin(TRF), The neutrophilic granulocyte count(NGC), Lymphocyte count(TLC), Serum c-reactive protein(CRP).The plasma and cell culture solution levels of IL-1β, IL-10, IL-6, TNF-α were measured by enzyme-linked immuno-sorbent assay (ELISA). Both groups of patients was comparable. RESULTS Both groups of patients treated after five days of postoperative were no significant differences. Prealbumin(PA) of both groups on day6were Significantly increased, whereas the study group was higher than control group. Generation of proinflammatory cytokines including IL-1β,IL-6and TNF-a by mononuclear leukocytes in the study group were markedly reduced than the control group, there were statistical differences between them(P<0.05), but level of IL-10by mononuclear leukocytes in two groups was slightly reduced. IL-6, IL-10and TNF-a of serum changed slightly in two groups, but IL-1β level of study group was reduced markedly than control group, there were statistical differences between them(P<0.05). HLA-DR expression of both groups on day6were Significantly increased, whereas the study group was higher than control group(P<0.05).The neutrophilic granulocyte count(NGC) and Serum c-reactive protein(CRP) of both groups were significantly reduced, and the study group was Significantly lower than control group.CONCLUSION Use of lipid infusions might allow us to combine intravenous alimentation with differential impact on immune and nutrition functions in patients with gastrointestinal caner after operation.