The Experimental Observation On Site Preservation In Mandibular Anterior Teeth Area With Osteoinduction Active Material

Objective:Through embedding Osteoinduction Active Material (OAM) immediately after pulling out the lateral incisors of both sides from the lower jaw of Beagle dogs, the OAM abilities of guiding the formation of new bone in the tooth socket after guided extraction are compared. Methods:Take six healthy male beagle dogs were randomly divided into A, B, C three groups, each group have two dogs. Extraction of both second mandibular lateral incisor in all the beagle use the method of minimally invasive. For group A, Osteoinduction Active Material (OAM) will be used and for group B, ohydroxyapatite bioceramics will be used. Group C will be left untreated (Control). Three groups of experimental dogs all put to death at the end of one month and the end of three month ago with three executed at each time respectively. The experimental samples will be used for Specimen measurements. And use of CBCT analysis for bone formation density estimates, finally HE dyeing bone grinding histological observation. Results:1. general observation shows two materials groups are better than blank group about alveolar ridge, alveolar ridge’s sites mucosa in blank group are obviously sag, and thave narrow width.2. loss of alveolar ridge width measurement showed that the OAM and hydroxyapatite bioceramics group significantly lower than the control group, the minimum loss of which the width of the OAM group (P<0.05). Alveolar ridge height loss measurement showed that the OAM and hydroxyapatite bioceramics are lower than the control group (P<0.05), but contrast differences between OAM and hydroxyapatite bioceramics has no statistical significance (P>0.05).3. CT value comparison shows:4weekend two materials CT values are significantly higher than control group (P<0.05), but there was no statistically significant difference between the two materials (P>0.05); The OAM below12weekend hydroxyapatite bioceramics (P<0.05), suggesting the OAM and hydroxyapatite bioceramics have good osteogenesis density, same OAM materials absorb quickly.4. HE dyeing observation:new bone formation are the most active OAM group, the early formation of new bone is more, new bone mature early. Hydroxyapatite bioceramics. Conclusion:Osteoinduction activity materials (OAM) can more quickly to induce new bone formation in the earlier, and it effect better than hydroxyapatite bioceramics that in alveolar ridge width preservation. It’s a good synthetic site preservation material.