Systems Pharmacology Dissecting The Therapeutic Mechanism Of Cardio-cerebrovascular Diseases By Traditional Chinese Mdicine

Holistic medicine is an inter-disciplinary field of study that integrates all types ofbiological information （protein, small molecules, tissues, organs, external environmentalsignals, etc.） to lead to predictive and actionable models for health care and diseasetreatment. Despite the holistic, global and integrative of this discipline, a comprehensivepicture of holistic medicine for the treatment of complex diseases is still lacking. In this study,we develop a novel systems pharmacology approach to dissect holistic medicine in treatingcardio-cerebrovascular diseases （CCDs） by TCM （traditional Chinese medicine）. Firstly,by applying the TCM active ingredients screened out by a systems-ADME process, weexplored the signed drug-target interactions for revealing the pharmacological actions ofdrugs at a molecule level. Then, at a/an tissue/organ level, the drug therapeutic mechanismswere further investigated by a target-organ location method. Finally, a translationalintegrating pathway approach was applied to extract the diseases-therapeutic modules forunderstanding the complex disease and its treatment at a systems level. For the first time, thefeature of the drug-target-pathway-organ-cooperation for treatment of multiple organ diseasesin holistic medicine was revealed and more importantly, facilitating the development of noveltreatment paradigm for complex diseases in the future.