The Role And Mechanism Of Guanxinping Of Anti-atherogenic Effect

ObjectiveObserved the regulation of Guanxinping to lipids (TC、TG、LDL-C、HDL-C), serum oxidized and antioxidant indicators (T-SOD、T-AOC、MDA、GSH、ox-LDL) inflammatory cytokines (Lox-1) of ApoE-/-mice model of atherosclerosis.MethodsApoE-/-mouse model of atherosclerosis were given normal diet, high fat diet model group, atorvastatin group (6.67mg/kg/d), coronary flat low-dose group (0.75g/kg/d), high-dose group (1.5g/kg/d). Treatment after3months, observed the different groups of lipids (TC、TG、 LDL-C、HDL-C), oxidation and antioxidant indicators(T-SOD、T-AO、MDA、GS、ox-LDL), inflammatory factors (Lox-1) of changes.ResultsGuanxinping can regulate the indicators of atherosclerosis ApoE-/-mouse model of lipids (TC、TG、LDL-C、HDL-C), oxidation and antioxidant indicators (T-SOD、T-AO、MDA、 GSH、ox-LDL), inflammatory cytokines (Lox-1)ConclusionGuanxinping with anti-atherosclerotic effect, presumably able related to djust their the indicators of lipids (TC、TG、LDL-C、HDL-C), serum oxidation and antioxidant (T-SOD、 T-AOC、MDA、GSH、ox-LDL),inflammatory cytokines (Lox-1) of ApoE-/-mouse model of atherosclerosis.