Clinical Observation Of Syndrome Differentiation And Treatment Combined With "Quadruple Therapy" On Chronic Gastritis With Helicobacter Pylori Infection

Objective:Compare the difference of Helicobacter pylori (Hp) eradication rate betwee n syndrome differentiation and treatment combined with "quadruple therapy" and "quadru ple therapy"; observe the efficience of syndrome differentiation and treatment combined with "quadruple therapy"and "quadruple therapy" on chronic gastritis in the process of er adicating Hp.Methods:60patients diagnosed with chronic gastritis and Hp infection were divided into two groups by random.30patients of the control group accepted the "standard quad ruple therapy"(omeprazole20mg, amoxicillin1.0g, clarithromycin0.5g, bismuth potassiu m citrate220mg, bid),30patients of the Test group accepted the "standard quadruple th erapy " and took herbs by syndrome differentiation at the same time. The course was10days. Patients then accepted13C urinary test or14C urea breath test four weeks after t he treatment. Statistically analyzed Hp eradication rate, clinical improvement of symptoms of two groups, and evaluated its safety.Results:TCM syndrome distribution of Chronic gastritis with Hp infection was as follo ws:Damp heat in spleen and stomach (37.9%)> disharmony between the liver and stomac h (31%)> weakness of the spleen and stomach (20.7%)> stomachyin deficiency (10.3%).Era dication rate was72.4%in the control group, and was93.3%in the experimental group. The difference of eradication rate between the control group and the experimental group was statistically significant (P<0.05).In addition, compared with quadruple therapy, syndr ome differentiation and treatment combined with "quadruple therapy" can significantly reli eve clinical symptoms like epigastric fullness, epigastric pain, belching, loss of appetite et c, but the difference was not statistically significant (P>0.05). The overall efficiency of the the control group was62.1%and was93.3%in the test group.The overall efficiency of the test group of symptoms was significantly higher, but the difference was not statis tically significant (P>0.05).1patient in the control group had a rash while taking the d rug test was terminated. Adverse events did not occur in the test group, the incidence of adverse events in both groups showed no significant difference in comparison (P>0.05).Conclusion:When comes to the treatment of chronic gastritis with H. pylori infectio n,the H. pylori eradication rate of both syndrome differentiation and treatment combined with "quadruple therapy" and "quadruple therapy" was statistically significant (P<0.05); Syndrome differentiation and treatment can significantly improve remission rates of sympt oms like epigastric fullness, epigastric pain, belching, loss of appetite etc.