Combination Of Heparin And Aspirin In Patients With Recurrent Pregnancy Loss And Positive Anti-phospholipid Antibodies: A Meta-analysis

Objective:Many clinical trials have demonstrated combination ofheparin and aspirin is superior to aspirin alone in enhancing live births inpatients with recurrent pregnancy loss and positive antiphospholipidantibodies. To assess whether this combination works better than aspirinalone,we carried a Meta-analysis through selecting RCTs.,which providesreliable evidence-based proof for clinic.Methods:We surveyed RCTs of the efficacy and safety ofcombination of heparin and aspirin in patients with recurrent pregnancyloss and APS using database like PubMed、MEDLINE、EMBASE andCNKI. Meta-analysis of RCTs was performed to determine treatmentefficacy and safety outcomes.Results:Nine RCTs were included. Combination of heparin andaspirin increase birth rate(RR=1.32，95%CI[1.22,1.42]，P<0.00001) whencompared to the aspirin alone.The Combination of heparin and aspirin hadno significance effect on the birth weight,preterm birth rate,fetal growthrestriction,preeclampsia and bleeding.Conclusions:Combination of heparin and aspirin is superior to aspirinalone in enhancing live births in patients with recurrent pregnancy loss andpositive antiphospholipid antibodies.