Analysis The Clinical And Pathological Factors Of Axillary Node Negtive Breast Cancer

Objective: Axillary lymph node dissection is an important part of thebreast cancer operation, but the cause of upper extremity lymphedema,dysfunction and other complications, is still a clinical problem. For avoidingunnecessary damage to the axillary lymph node dissection and formulate theindications of sentinel lymph node biopsy. This paper studies theclinicopathological factors of axillary lymph node metastases (axillarylymph nodes metastasis, ALNM), build a mathematical model of ANNBC,will be helpful to Before surgery predict ALNM case before surgery, it hasimportant guiding significance to assessment of prognosis and to choose theright assisted therapy. Methods: A retrospective analysis of600cases in ourhospital with integrality clinical data, and after surgery, pathology confirmedwith primary breast cancer and breast cancer, study their age, menopausalstatus, imaging lymph node enlargement, primary tumor size, aspect ratio,tumor location, distance from the nipple and areola, histological type, Her2gene amplification, ER, PR, Ki67, P53and the presence of preoperativechemotherapy, logistic regression analysis was performed to establish theregression equation. Results: Univariate analysis showed that: imaging lymph nodes, tumor aspect ratio, T stage, quadrant, the distance from thenipple and areola, histological type and presence of preoperativechemotherapy, those seven factors associated with axillary lymph nodemetastasis (P <0.05), while the patient’s age, menopausal status, Her2geneamplification, ER, PR, Ki67, P53has no association with axillary lymphnode metastasis(P≥0.05).Multivariate logistic regression analysis showedthat the imaging lymph nodes, preoperative chemotherapy, the tumor islocated in the upper outer quadrant is the risk factors of axillary lymph nodemetastasis. Conclusions:1Imaging lymph node enlargement, the aspectratio of the tumor, T stage, tumor located in quadrant, distance from thenipple and areola, histological type, presence of preoperative chemotherapyseven factors affecting axillary lymph node metastasis was statisticallysignificant.2Imaging without axillary lymph nodes, the distance from thenipple and areola5-5.9cm, special non-invasive cancer, no preoperativechemotherapy is the probability of axillary node negative breast cancer.