The Predictive Value Of Cox-2and Salusin-a In The Risk Stratification Of Acute Coronary Sydrome

Objective：Atherosclerosis(AS) can cause coronary,brain and renalvascular lesion which do serious harm to the mankind.Inflammation andlipid plays a very important role in the genesis and development of theatherosclerosis.The aim of this study is to explore the relationship betweenthe inflammatory factor of Cox-2and lipid factor of Salisin-a in the processof atherosclerosis(AS),analyse its predictive value in the risk stratificationof acute coronary sydrome，and know the correlation between the numberof the main risk factor(Hypertension、Hyperlipidemia、Diabete) and thelevel of Cox-2.Methods：one hundred and ten patients who had results in cornaryangiography(CAG) were divided into three goups:ACS group(n=61),stableangina pectoris (SAP) group (n=19),and Control group (n=30) who hadnegative results in CAG according to their medical histories and CAGresults. The ACS group (n=61) was divided into an acute myocardialinfarction (AMI) group and unstable angina pectoris (UAP) group in further.The patients were also divided into a＜30score group and a≥30score group based on the Gensini scoring system. In addition,the patientwith ACS were divided into single main risk factor group and multi-mainrisk factors group acorrding to the number of the main risk factors.Theplasma Cox-2and Salusin-a levels were measured by ELISA kit。Results：The level of plasma Cox-2and hs-CRP were significantlyhigher in the ACS group than in the SAP group and the Controlgroup[(16.39±3.64) vs（13.79±1.76）、（13.38±1.98）ng/ml；1.9（083-7.61）vs1.4（0.47-1.96）、0.87（0.56-1.84） mg/L, P＜0.01].and the level ofplasma Cox-2and hs-CRP were signifcantly higher in the AMI group thanin the UAP group [（18.88±3.97）Vs (15.09±2.70) ng/ml；6.01（1.76-20）vs1.31（0.68-4.59）mg/L, P＜0.05]. Though the level of Salusin-a waslower in the ACS group and SAP group than in the Controlgroup[（0.13±0.07）、（0.11±0.04） vs (0.18±0.08) ng/ml, P＜0.01], it wasnot significantly different between in the ACS group and the SAPgroup.The level of Cox-2and hs-CRP have not significantly differentbetween in the single main risk factor group and the muti-main risk factors.Conclusion：1.The inflammatory factor of Cox-2and hs-CRP couldhave prodictive value in the risk stratification of acute coronarysydrome.2.The lipid factor of Salisin-a may be associate with coronaryatherosclerosis.3.In addition,we find that the number of the main riskfactor may not have the correlation with the level of Cox-2.