TNF Receptor-associated Factor5Gene Confers Genetic Predisposition To Acute Anterior Uveitis And Pediatric Uveitis

Introduction: TNF Receptor-Associated Factor5(TRAF5) has beenshown to be associated with autoimmune disease. The current study soughtto investigate the potential association of TRAF5with acute anterior uveitis(AAU) and pediatric uveitis in Han Chinese.Methods：ThreeTRAF5SNPs were analyzed in450AAU patients withor without ankylosing spondylitis (AS),458pediatric uveitis patients, and1,601healthy controls by using polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP) or TaqMan SNP GenotypingAssay. Numerous variables were evaluated, including age, sex distribution,and clinical and laboratory observations.Results: Two SNPs (rs6540679, rs12569232) of TRAF5wereassociated with pediatric uveitis, and rs12569232also showed a relationwith the presence of microvascular leakage. No significant associationswere found when patients were subdivided according to their rheumatoidfactor (RF) or anti-nuclear antibody (ANA) status or whether they hadjuvenile idiopathic arthritis (JIA). Rs12569232predisposed to AAU and itssubgroups (with ankylosing spondylitis (AS) or HLA-B27positive). Noassociation was found between rs10863888and either pediatric uveitis orAAU.Conclusion: This study revealed that TRAF5is involved in thedevelopment of AAU and pediatric uveitis. Further stratified analysis according to the clinical and laboratory observations suggested thatrs12569232/TRAF5may play a role in the development of retinalvasculitis.