Recent Advances In The Research Of Hydrogen Sulfide And Alzheimer’s Disease

Hydrogen sulfide (H2S) is referred to as the third gaseous mediatoralongside NO and CO[1].Nearly20years’ research revealed, H2S is aphysiologically important molecule in the central nervous system, such askeeping neurons and the nerve tissues from the inflammation induced byβ-amyloid (Aβ), lipopolysaccharide, homocysteine, MPP+, apoptosis andoxidative stress injury. H2S plays an important neuromodulator andneuroprotective effect in these ways. Experiments in vitro and in vivoshowed, H2S level’s decrease leads to a variety of metabolic pathwaysdysfunction and cell damage, its pathological changes and significantlyimproved clinical manifestations were obtained after adding exogenousH2S, indicating that H2S may be involved in pathogenesis ofneurodegenerative diseases. Clinical trials found that plasma H2S levels arenegatively correlated with the severity of AD and a number of degenerativediseases of the nervous system in the body of the patients, and the severityof the level associated with the disease[2]. In this paper, the researchprogress on H2S and AD were reviewed.