Effects Of Blood Cardioplegia With Exogenous Creatine Phosphate On CTnI And Life Quality In Patients With Heart Valve Replacement

Objective:To observe the effects of blood cardioplegia with exogenous creatine phosphate on cTnI and life quality in patients with heart valve replacementMethods:80patients who were going to undergo mitral or aortic heart valve replacement surgeries were randomly divided into two groups. Patients in the control group (n=40) were treated with common blood cardioplegia, and patients in the study group (n=40) were treated with blood cardioplegia filled with10mmol/L creatine phosphate. Central venous blood samples were taken to determine the concentrations of cTnl before cardiopulmonary bypass, and at6h,24h and48h after aortic open-clamp. Perioperative recovery condition was observed. The SF-36Form was used to evaluate the quality of life12to15months after surgery.Results:Compared to the control group, the levels of cTnl at6h,24and48h after aortic open-clamp were significantly lower (all P values <0.05), the rate of spontaneous beating was significantly higher (P<0.05), the usage of dopamine hydrochloride after surgery was significantly lower (P<0.05), and the quality of life after surgery, in dimensionality of PF, RP, GH and VT, had been significantly improved (P <0.05).Conclusions:Blood cardioplegia with creatine phosphate decreased cTnI level,showed effective myocardial protection and improved the quality of life after surgery in patients with heart valve replacement.