| BackgroundWith the rapid social and economic development, improving people’s living standards,significantly higher incidence of coronary heart disease, and the trend is clearly younger.Coronary heartdisease (CHD) as a high-fat, common cardiovascular disease, a serious threat to people’s health hasseriously affected the quality of life,and its causes complex, now that genetic, environmental, lifestyle, diet,obesity are related to its main pathological changes of atherosclerosis, plaque formation, such as coronaryartery stenosis. With the deepening of research in recent years, high-sensitivity C-reactive protein (hs-CRP),brain natriuretic peptide (BNP), adiponectin (APN) and coronary heart disease (CHD) correlation bydomestic and foreign scholars, experts and widespread concern clinicians, but also to do some research.However, in order to study the relationship between a single multi-index and coronary heart disease[1],andtherefore, the greatest significance of this study is that through the joint detection of coronary artery diseasein patients with hs-CRP, correlation between BNP, APN plasma levels and coronary heart disease assessedthree further explore the clinical significance of the three coronary heart disease, assess the condition,evaluate the efficacy, prognosis.ObjectiveDiscuss the relationship between hs-CRP, BNP, APN and CHD. Evaluate the relationshipbetween the three. Analysis of results of the three coronary stenosis correlation.MethodsCase collection: In a tertiary level hospital,randomly select101cases confirmed by coronaryangiography in patients with coronary artery disease, among that34patients are acute myocardialinfarction (AMI),33patients are unstable angina pectoris (UAP),34patients are stable angina pectoris(SAP) patients;30healthy volunteers are as a control group. Serum high-sensitivity C-reactive proteinlevels are measured using latex turbidimetry, and Natriuretic peptide levels use chemiluminescentmicroparticle immunoassay method for the determination, and Serum adiponectin levels by enzyme-linkedimmunosorbent assay (ELISA) is measured, at last Compare the correlation among the three groups.Calculat101cases of patients with coronary artery disease severity according to Gensini score approach. Statistical Methods: Use SPSS11.5establish a database for statistical analysis. Themeasurement data use (±s), and use the t-test between the two sample, and multiple samples arecompared using analysis of variance, correlation analysis between the two numeric variables spearman. P<0.05statistically significant difference, and P <0.01is considered statistically significant.Results1. An acute myocardial infarction (AMI) group of hs-CRP, BNP, APN concentrations are (10.27±4.43) mg/L,(1643.80±1516.72) pg/ml,(307.82±189.57) ug/ml, and the healthy controlgroup’s hs-CRP, BNP, APN concentrations are (3.98±2.19) mg/L,(71.56±18.89) pg/ml,(968.13±292.64) ug/ml, respectively, compared to the significant difference is statistically significant (t=7.05,5.68,-10.84, P <0.01).2. The Concentration of UAP group’s hs-CRP, BNP, APN are (7.72±5.03mg/L),(1352.90±1168.71) pg/ml,(380.02±281.41) of ug/ml, with healthy controls, hs–CRP, BNP, APN’ sconcentrations are (3.98±2.19)mg/L,(71.56±18.89) pg/ml,(968.13+292.64) ug/ml. The differences arestatistically significant (t=3.77,6.00,-8.13, P <0.01).3. There is no statistically significant difference compared with SAP group’s hs-CRPconcentration (4.88±4.18) mg/L and healthy controls’hs-CRP concentration (3.98±2.19)mg/L,(t=-1.05, P>1.05). The difference are statistically significant between the SAP group’s concentration of BNP,APN respectively (1083.82±931.92) pg/ml,(617.13±326.07) ug/ml, and the concentration of BNP,APN (71.56±18.89) pg/ml,(968.13±292.64) ug/ml in healthy controls (t=5.94,-4.50, P <0.01).4. Hs-CRP for AMI group (10.27±4.43) mg/L compared with UAP group’s hs-CRP(7.72±5.03) mg/L is statistically significant difference (t=2.20, P <0.05); There is no statisticallysignificant difference between AMI group’s BNP (1643.80±1516.72) pg/ml and UAP group’s BNP(1352.90±1168.71) pg/ml,(t=0.88, P>0.05); There is no statistically significant difference betweenAMI group’s APN (307.82±189.57) ug/ml and UAP group’s APN (380.02±281.41) ug/ml (t=-1.23,P>0.05). 5.The hs-CRP (10.27±4.43) mg/L, APN (307.82±189.57) ug/ml of AMI group and the hs-CRP (4.88±4.18) mg/L, APN (617.13±326.07) ug/ml of SAP group compared with difference isstatistically significant (t=5.16,0.001, P <0.01); There is no statistically significant difference betweenAMI group’s BNP (1643.80±1516.72) pg/ml and SAP group’s BNP concentration (1083.82±931.92)pg/ml (t=1.83, P>0.05).6. Compare the hs-CRP (7.72±5.03) mg/L, APN (380.02±281.41) ug/ml of UAP group,and hs-CRP (4.88±4.18) mg/L respectively, APN (617.13±326.07) ug/ml of SAP group isstatistically significant difference (t=2.52,-3.18, P <0.05); there was no statistically significant differencebetween UAP group’s BNP (1352.90±1168.71) pg/ml and SAP group’ s BNP concentration (1083.82±931.92) pg/ml (t=1.04, P>0.05).7. Correlation analysis7.1Each group of hs-CRP, BNP, APN and imaging results of correlation analysis7.1.1In AMI group of hs-CRP and BNP, APN and imaging results of no correlation (r=0.154,-0.136,0.269, P>0.05); The BNP and APN has no correlation (r=-0.127, P>0.05), and the imagingresults into positive correlation (r=0.441, P <0.01); APN and imaging results has no correlation (r=0.206,P>0.05).7.1.2Hs-CRP in group UAP and BNP has a negative correlation (r=-0.380, P <0.05), andthe APN has no correlation (r=-0.237, P>0.05), and the imaging results are into positive correlation (r=0.458, P <0.01); BNP and APN is into positive correlation (r=0.408, P <0.05), and the imaging resultshas no correlation (r=-0.238, P>0.05); APN and imaging results are negative correlation (r=-0.363, P<0.05).7.1.3In SAP group the hs-CRP has no correlation with BNP(r=0.293, P>0.05), and hasnegatively correlated with APN(r=-0.473, P <0.01), and has a positive correlation with the imagingresults(r=0.350, P <0.05); There is negatively correlated (r=-0.389, P <0.05)with BNP and APN, andshows no correlation (r=0.084, P>0.05) with the imaging results; There is negatively correlated(r=-0.433, P <0.05) between APN and the imaging results.7.1.4In the control group the hs CRP and BNP, APN have no correlation (r=-0.097,-0.225, P>0.05); The BNP and APN has no correlation (r=0.157, P>0.05). 7.2The correlation analysis of hs-CRP, BNP, APN and imaging results in CHDIn CHD the hs-CRP has no correlation with the BNP (r=0.083, P>0.05), has negativecorrelation with the APN (r=-0.427, P <0.01), and has positive correlation with the imaging results (r=0.527, P <0.01); The BNP and APN has no correlation (r=-0.100, P>0.05), and has the positivecorrelation with the imaging results (r=0.249, P <0.05); APN and the imaging results has negativecorrelation (r=-0.418, P <0.01).Conclusion The level of hs-CRP, BNP, APN is closely related to the occurrence of coronaryheart disease, that suggests the three markers can be used as the risk of coronary heart disease diagnosis.Combined detection of serum hs-CRP, BNP, APN levels can effectively predict the severity of coronaryheart disease, diagnosis, illness evaluation in patients with coronary heart disease. That has a certainclinical significance. |
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